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Clinical trialNCT03385057WithdrawnPhase 1Interventional

Postoperative Ibuprofen Use and Risk of Bleeding in Pediatric Tonsillectomy

SponsorMassachusetts Eye and Ear InfirmaryEnrollment0Tonsillectomy With or Without Adenoidectomy
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Pediatric tonsillectomy is one of the most common surgical procedures annually in the United States; risks include postoperative hemorrhage and poor pain control. Controversy exists regarding optimal pharmacologic pain management following surgery, as each drug's efficacy is balanced by its specific side effects. Ibuprofen is effective in controlling postoperative pain following tonsillectomy, but its mechanism of action results in decreased platelet function, which may increase postoperative bleeding events. This is a multicenter, randomized control non-inferiority trial designed to assess the relationship between short-course ibuprofen use and post-tonsillectomy bleeding when compared to acetaminophen.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Rady'S Children'S Hospital

    San Diego, California, United States

  • Emory University and Children'S Healthcare of Atlanta

    Atlanta, Georgia, United States

  • Case Western University- Raimbow Babies and Children'S

    Cleveland, Ohio, United States

  • Portsmouth Naval Hospital

    Portsmouth, Virginia, United States

  • Madigan Army Hospital

    Tacoma, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Acetaminophen →Ibuprofen →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Sept 2018
Primary completion
1 Jan 2023
Completion
1 Jan 2023
Last update posted
20 Sept 2018
Registered enrollment
0
Registry id
NCT03385057
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.