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Clinical trialNCT03395587Active, not recruitingPhase 2Interventional

Efficiency of Vaccination with Lysate-loaded Dendritic Cells in Patients with Newly Diagnosed Glioblastoma

SponsorHeinrich-Heine University, DuesseldorfEnrollment136Glioblastoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The primary objective of the study is to determine whether overall survival of newly diagnosed glioblastoma patients treated with lysate-loaded, mature dendritic cell vaccines as add-on to the standard of care consisting of resection, radiotherapy with concomitant temozolomide chemotherapy and subsequent adjuvant temozolomide chemotherapy is superior to the treatment with the standard of care alone.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Germany
  • Klinik Für Neurologie, Knappschaftskrankenhaus Bochum

    Bochum, North Rhine-Westphalia, Germany

  • Klinik Für Neurochirurgie, Sana Kliniken Duisburg

    Duisburg, North Rhine-Westphalia, Germany

  • Neurochirurgische Klinik, Universitätsklinikum Düsseldorf

    Düsseldorf, North Rhine-Westphalia, Germany

  • St. Marien Hospital Lünen, Klinik Für Neurochirurgie

    Lünen, North Rhine-Westphalia, Germany

  • Klinik Für Allgemeine Neurologie, Universitätsklinikum Münster

    Münster, North Rhine-Westphalia, Germany

  • Helios Klinikum Krefeld, Klinik Für Neurochirurgie

    Krefeld, Germany

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Autologous, tumor lysate-loaded, mature dendritic cellsStandard Therapy
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
6 Mar 2018
Primary completion
31 May 2027
Completion
31 May 2027
Last update posted
2 Dec 2024
Registered enrollment
136
Registry id
NCT03395587
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.