Clinical trialNCT03416790CompletedObservational

IMPAACT 2015 - Evaluation of the HIV-1 Reservoir in the Central Nervous System of Perinatally-Infected Youth and Young Adults With Cognitive Impairment

SponsorInternational Maternal Pediatric Adolescent AIDS Clinical Trials GroupEnrollment24HIV-1-infection

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

IMPAACT 2015 is a cross-sectional, exploratory study that will investigate the central nervous system (CNS) reservoir in perinatally HIV-infected adolescents and young adults on effective antiretroviral therapy with neurocognitive impairment. The study will assess the frequency with which HIV is detected in the cerebral spinal fluid (CSF) in this population and assess whether detectable HIV in the CSF correlates with markers of inflammation and neuronal injury. Findings from this study will advance understanding of the role of the CNS in HIV-1 persistence and its implications for future HIV-1 remission research.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Ann Chahroudi, MD, PhD
Emory University
Study Chair
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Thor Wagner, MD
University of Washington
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico

University of Puerto Rico Pediatric Hiv/aids Research Program (crs 6601)
San Juan, Puerto Rico

United States

David Geffen School of Medicine at University of California, Los Angeles (crs 5112)
Los Angeles, California, United States
University of Southern California (crs 5048)
Los Angeles, California, United States
University of California, San Diego Mother-Child-Adolescent Hiv Program (crs 4601)
San Diego, California, United States
University of Colorado, Denver (crs 5052)
Aurora, Colorado, United States
Emory University School of Medicine (crs 5030)
Atlanta, Georgia, United States
Johns Hopkins University (crs 5092)
Baltimore, Maryland, United States
Boston Medical Center Pediatric Hiv Program (crs 5011)
Boston, Massachusetts, United States
Bronx-Lebanon Hospital Center (crs 5114)
The Bronx, New York, United States
Jacobi Medical Center (crs 5013)
The Bronx, New York, United States
St. Jude Children'S Research Hospital (crs 6501)
Memphis, Tennessee, United States
Seattle Children'S Hospital (crs 5017)
Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 6 Feb 2019
Primary completion: 26 Mar 2020
Completion: 26 Mar 2020
Last update posted: 8 Jul 2020
Registered enrollment: 24
Registry id: NCT03416790

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.