Clinical trialNCT03473223CompletedPhase 3Interventional

Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

SponsorCSL BehringEnrollment18,226Acute Coronary Syndrome

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events \[MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke\] in subjects with acute coronary syndrome (ACS) diagnosed with either ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI), including those managed with percutaneous coronary intervention (PCI) or medically managed.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Danielle Duffy, MD
CSL Behring - Executive Director, Clinical Development - CV & Metabolism
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

903 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

0320069 - Hospital Italiano Regional del Sur
Bahía Blanca, Argentina
0320020 - Clinica Privada
Buenos Aires, Argentina
0320025 - Fundación Sanatorio Güemes
Ciudad Autonoma Buenos Aires, Argentina
0320019 - Hospital Británico de Buenos Aires
Ciudad Autónoma Buenos Aires, Argentina
0320029 - Instituto Cardiovascular de Buenos Aires
Ciudad Autónoma Buenos Aires, Argentina
0320033 - Corporacion Medica de San Martin
Ciudad Autónoma Buenos Aires, Argentina
0320034 - Clinica Adventista Belgrano
Ciudad Autónoma Buenos Aires, Argentina
0320041 - Clinica Y Maternidad Suizo Argentina (cymsa)
Ciudad Autónoma Buenos Aires, Argentina
0320013 - Hospital Municipal de Coronel Suárez
Coronel Suárez, Argentina
0320040 - Instituto de Cardiología de Corrientes
Corrientes, Argentina
0320012 - Sanatorio Allende
Córdoba, Argentina
0320015 - Clinica Chutro S.R.L.
Córdoba, Argentina
0320023 - Clínica Privada del Prado
Córdoba, Argentina
0320026 - Clínica Colombo
Córdoba, Argentina
0320036 - Hospital Italiano
Córdoba, Argentina
0320039 - Santatorio Parque S.A.
Córdoba, Argentina
0320063 - Clinica Romagosa
Córdoba, Argentina
0320014 - Hospital Italiano la Plata
La Plata, Argentina
0320016 - Sanatorio Modelo Quilmes
Quilmes, Argentina
0320017 - Entidades Vinculadas Al Sanatorio Parque
Rosario, Argentina
0320044 - Instituto Medico de la Fundacion de Estudios Clínicos
Rosario, Argentina
0320071 - Hospital Provincial del Centenario
Rosario, Argentina
0320070 - Hospital Papa Francisco
Salta, Argentina
0320073 - Instituto Medico de Alta Complejidad - Imac
Salta, Argentina
0320022 - Hospital El Cruce
San Juan Bautista, Argentina
0320037 - Centro Privado de Cardiologia (cpc)
San Miguel de Tucumán, Argentina
0320027 - Estudios Clínicos de Los Arroyos
San Nicolás, Argentina
0320021 - Sanatorio Medico de Diagnostico Y Tratamiento S.A.
Santa Fe, Argentina
0320032 - Hospital Dr. Jose Maria Cullen
Santa Fe, Argentina
0320038 - Sanatorio Mayo Privado S.A.
Santa Fe, Argentina
0320067 - Sanatorio Santa Rosa
Santa Rosa, Argentina
0320054 - Clínica Privada de Especialidades Médicas de Villa María
Villa María, Argentina

Australia

0360087 - Campbelltown Hospital
Campbelltown, New South Wales, Australia
0360069 - Liverpool Hospital
Liverpool, New South Wales, Australia
0360070 - Royal North Shore Hospital
St Leonards, New South Wales, Australia
0360071 - Wollongong Hospital
Wollongong, New South Wales, Australia
0360063 - Cairns Base Hospital
Cairns, Queensland, Australia
0360062 - the Prince Charles Hospital
Chermside, Queensland, Australia
0360061 - Royal Brisbane Hospital
Herston, Queensland, Australia
0360060 - Gold Coast Hospital
Southport, Queensland, Australia

863 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Apolipoprotein A-I [human]

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 21 Mar 2018
Primary completion: 16 Feb 2023
Completion: 17 Nov 2023
Last update posted: 14 Jan 2025
Registered enrollment: 18,226
Registry id: NCT03473223

Cross-registrations

EU-CTR / CTIS (EudraCT)2017-000996-98

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.