Clinical trialNCT03504644Active, not recruitingPhase 1/PHASE2Interventional

Venetoclax and Vincristine in Treating Patients With Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia

SponsorECOG-ACRIN Cancer Research GroupEnrollment40Recurrent Adult Lymphoblastic LymphomaRecurrent B Acute Lymphoblastic LeukemiaRecurrent B Lymphoblastic LymphomaRecurrent T Acute Lymphoblastic LeukemiaRecurrent T Lymphoblastic LymphomaRefractory B Acute Lymphoblastic Leukemia+3 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase Ib/II trial studies the side effects and best dose of venetoclax and how well it works when given together with vincristine in treating patients with T-cell or B-cell acute lymphoblastic leukemia that has come back (recurrent) or does not respond to treatment (refractory). Venetoclax may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Chemotherapy drugs, such as vincristine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving venetoclax together with vincristine may work better in treating patients with acute lymphoblastic leukemia compared to vincristine alone.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Neil D Palmisiano
ECOG-ACRIN Cancer Research Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

170 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico

Cancer Center-Metro Medical Center Bayamon
Bayamón, Puerto Rico
Puerto Rico Hematology Oncology Group
Bayamón, Puerto Rico
Doctors Cancer Center
Manati, Puerto Rico
Centro Comprensivo de Cancer de Upr
San Juan, Puerto Rico
Proncology
San Juan, Puerto Rico
San Juan City Hospital
San Juan, Puerto Rico
San Juan Community Oncology Group
San Juan, Puerto Rico

United States

Alaska Breast Care and Surgery Llc
Anchorage, Alaska, United States
Alaska Oncology and Hematology Llc
Anchorage, Alaska, United States
Alaska Women'S Cancer Care
Anchorage, Alaska, United States
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States
Anchorage Oncology Centre
Anchorage, Alaska, United States
Anchorage Radiation Therapy Center
Anchorage, Alaska, United States
Katmai Oncology Group
Anchorage, Alaska, United States
Providence Alaska Medical Center
Anchorage, Alaska, United States
Mayo Clinic Hospital in Arizona
Phoenix, Arizona, United States
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Mercy Hospital Fort Smith
Fort Smith, Arkansas, United States
Carti Cancer Center
Little Rock, Arkansas, United States
Providence Saint Joseph Medical Center/disney Family Cancer Center
Burbank, California, United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, United States
Smilow Cancer Center/yale-New Haven Hospital
New Haven, Connecticut, United States
Yale University
New Haven, Connecticut, United States
Mayo Clinic in Florida
Jacksonville, Florida, United States
University of Florida Health Science Center - Jacksonville
Jacksonville, Florida, United States
Saint Luke'S Cancer Institute - Boise
Boise, Idaho, United States
Saint Luke'S Cancer Institute - Fruitland
Fruitland, Idaho, United States
Saint Luke'S Cancer Institute - Meridian
Meridian, Idaho, United States
Saint Luke'S Cancer Institute - Nampa
Nampa, Idaho, United States
Saint Luke'S Cancer Institute - Twin Falls
Twin Falls, Idaho, United States
Saint Anthony'S Health
Alton, Illinois, United States
Illinois Cancercare-Bloomington
Bloomington, Illinois, United States
Loyola Center for Health at Burr Ridge
Burr Ridge, Illinois, United States
Illinois Cancercare-Canton
Canton, Illinois, United States
Memorial Hospital of Carbondale
Carbondale, Illinois, United States
Sih Cancer Institute
Carterville, Illinois, United States
Illinois Cancercare-Carthage
Carthage, Illinois, United States
Centralia Oncology Clinic
Centralia, Illinois, United States
Saint Mary'S Hospital
Centralia, Illinois, United States
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, United States

130 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Venetoclax →Vincristine LiposomalVincristine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 13 Aug 2018
Primary completion: 22 Jul 2025
Completion: 31 Dec 2028
Last update posted: 7 Aug 2026
Registered enrollment: 40
Registry id: NCT03504644

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.