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Clinical trialNCT03516708RecruitingPhase 1/PHASE2Interventional

Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

SponsorWashington University School of MedicineEnrollment49Rectal Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this research study is to evaluate epacadostat when given with routine radiation therapy and chemotherapy (capecitabine and oxaliplatin) to treat rectal cancer before routine surgery is performed to remove the tumor.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of California Irvine - Chao Family Comprehensive Cancer Center

    Orange, California, United States

    Withdrawn
  • Dana Farber Cancer Institute

    Boston, Massachusetts, United States

    Haeseong Park, M.D., MPH
    Recruiting
  • Henry Ford Cancer Institute

    Detroit, Michigan, United States

    Withdrawn
  • Washington University School of Medicine

    St Louis, Missouri, United States

    Benjamin Tan, M.D.Esther Lu, Ph.D.Kian-Huat Lim, M.D.Matthew Ciorba, M.D.Matthew Mutch, M.D.Matthew Silveira, M.D.Moh'd Khushman, M.D.Nikolaos Trikalinos, M.D.Olivia Aranha, M.D., Ph.D.Patrick Grierson, M.D. Ph.D.Paul Wise, M.D.Rama Suresh, M.D.Salman Chaudhry, M.D.Steven Hunt, M.D.William Chapman, Jr., M.D. Ph.D.
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CAPOX chemotherapyEpacadostatFOLFOX chemotherapy
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
6 Jan 2020
Primary completion
15 Jul 2027
Completion
12 Aug 2030
Last update posted
11 Feb 2026
Registered enrollment
49
Registry id
NCT03516708
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.