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Clinical trialNCT03522142TerminatedPhase 1Interventional

A Study Exploring the Safety and Tolerability of INCB081776 in Participants With Advanced Malignancies

SponsorIncyte CorporationEnrollment83Advanced Solid Tumors
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, pharmacodynamics, and early clinical activity of single-agent INCB081776 (Part 1) and INCB081776 in combination with INCMGA00012 (Part 2).

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

18 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Denmark
  • Rigshospitalet Uni of Hospital of Copenhagen

    Copenhagen, Denmark

  • Odense University Hospital

    Odense C, Denmark

Netherlands
  • Netherlands Cancer Institute Antoni Van Leeuwenhoek Ziekenhuis

    Amsterdam, Netherlands

  • University Medical Center Groningen

    Groningen, Netherlands

  • Erasmus Medical Center

    Rotterdam, Netherlands

Norway
  • Haukeland University Hospital

    Bergen, Norway

  • Utprøvingsenheten, Oslo University Hospital Radiumhospitalet

    Oslo, Norway

Sweden
  • Skane University Hospital Lund

    Lund, Sweden

  • Karolinska University Hospital Solna

    Stockholm, Sweden

United States
  • Yale Cancer Center

    New Haven, Connecticut, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, United States

  • Hackensack University Medical Center

    Hackensack, New Jersey, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, United States

  • University of Pennsylvania Abramson Cancer Center

    Philadelphia, Pennsylvania, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, United States

  • Sarah Cannon Research Institute

    Nashville, Tennessee, United States

  • Md Anderson Cancer Center

    Houston, Texas, United States

  • University of Wisconsin Carbone Cancer Center

    Madison, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

INCB081776INCMGA00012
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
27 Aug 2018
Primary completion
10 Sept 2025
Completion
10 Sept 2025
Last update posted
9 Oct 2025
Registered enrollment
83
Registry id
NCT03522142

Cross-registrations

EU-CTR / CTIS (EudraCT)2020-004867-26EU-CTR / CTIS (EudraCT)2023-504499-29-00

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.