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Clinical trialNCT03535298Active, not recruitingPhase 4Interventional

Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS

SponsorThe Cleveland ClinicEnrollment800Multiple Sclerosis, Relapsing-Remitting
View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

30 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United Kingdom
  • University Hospitals Coventry and Warwickshire

    Coventry, England, United Kingdom

  • the Leeds Teaching Hospitals Nhs Trust, Leeds General Infirmary

    Leeds, England, United Kingdom

  • University Hospitals Leicester

    Leicester, England, United Kingdom

  • Imperial College Healthcare Nhs Trust, Charing Cross Hospital

    London, England, United Kingdom

  • University College London Hospitals Nhs Foundation Trust, University College Hospital

    London, England, United Kingdom

  • Salford Royal Nhs Foundation Trust, Salford Hospital

    Manchester, England, United Kingdom

  • Oxford University Hospitals Nhs Foundation Trust, John Radcliffe Hospital

    Oxford, England, United Kingdom

  • University Hospitals Plymouth Nhs Trust, Derriford Hospital

    Plymouth, England, United Kingdom

  • Sheffield Teaching Hospitals

    Sheffield, England, United Kingdom

  • University Hospitals of North Midlands

    Stoke, England, United Kingdom

  • Royal Infirmary of Edinburgh

    Edinburgh, Scotland, United Kingdom

  • Cardiff and Vale University Local Health Board, University Hospital of Wales

    Cardiff, Wales, United Kingdom

  • Aneurin Bevan Local Health Board Headquarters, Royal Gwent Hospital

    Newport, Wales, United Kingdom

  • Swansea Bay University Local Health Board, Morriston Hospital

    Swansea, Wales, United Kingdom

  • Nottingham University Hospitals Nhs Trust, Queens Medical Centre

    Nottingham, United Kingdom

United States
  • University of Colorado-Anschutz Medical Campus

    Aurora, Colorado, United States

  • University of Minnesota

    Minneapolis, Minnesota, United States

  • Mayo Clinic

    Rochester, Minnesota, United States

  • Cleveland Clinic Lou Ruvo Center for Brain Health

    Las Vegas, Nevada, United States

  • University of Buffalo

    Buffalo, New York, United States

  • University Rochester Medical Center

    Rochester, New York, United States

  • University of Cincinnati

    Cincinnati, Ohio, United States

  • Cleveland Clinic

    Cleveland, Ohio, United States

  • Ohio Health

    Columbus, Ohio, United States

  • Ut-Austin

    Austin, Texas, United States

  • Baylor College of Medicine, Houston

    Houston, Texas, United States

  • Uthealth-Houston

    Houston, Texas, United States

  • University of Virginia

    Charlottesville, Virginia, United States

  • Virginia Commonwealth University

    Richmond, Virginia, United States

  • University of Wisconsin-Madison

    Madison, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
3 Jan 2019
Primary completion
30 Jul 2027
Completion
30 Jul 2027
Last update posted
28 Aug 2025
Registered enrollment
800
Registry id
NCT03535298

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.