Clinical trialNCT03550391RecruitingPhase 3Interventional

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

SponsorCanadian Cancer Trials GroupEnrollment206Brain Metastases

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Stereotactic radiosurgery (SRS) is a commonly used treatment for brain tumors. It is a one-day (or in some cases two day), out-patient procedure during which a high dose of radiation is delivered to small spots in the brain while excluding the surrounding normal brain. Whole brain radiation therapy with hippocampal avoidance (HA-WBRT) is when radiation therapy is given to the whole brain, while trying to decrease the amount of radiation that is delivered to the area of the hippocampus. The hippocampus is a brain structure that is important for memory. Memantine is a drug that is given to help relieve symptoms that can be caused by WBRT, including problems with memory and other mental symptoms. Health Canada, the regulatory body that oversees the use of drugs in Canada, has not approved the sale or use of memantine in combination with WBRT to treat this kind of cancer, although they have allowed its use in this study.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

David Roberge
CHUM-Centre Hospitalier de l'Universite de Montreal
Study Chair
clinicaltrials.gov ↗
Michael Chan
Wake Forest School of Medicine, Winston-Salem, NC
Study Chair
clinicaltrials.gov ↗
Vina Gondi
Northwestern Medicine Cancer Center, Warrenville IL
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

86 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Arthur J E Child Comprehensive Cancer Centre
Calgary, Alberta, Canada
Muhammad S. Faruqi
Recruiting
Cross Cancer Institute
Edmonton, Alberta, Canada
Samir I. Patel
Recruiting
Bcca-Vancouver Cancer Centre
Vancouver, British Columbia, Canada
Alan M. Nichol
Recruiting
Qeii Health Sciences Centre/nova Scotia Health Authority
Halifax, Nova Scotia, Canada
Michael N. Ha
Recruiting
Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Ontario, Canada
Active, not recruiting
London Regional Cancer Program
London, Ontario, Canada
Melody Qu
Recruiting
University Health Network-Princess Margaret Hospital
Toronto, Ontario, Canada
David B. Shultz
Recruiting
Csss Champlain-Charles Le Moyne
Greenfield Park, Quebec, Canada
Suspended
Chum - Centre Hospitalier de L'Universite de Montreal
Montreal, Quebec, Canada
David Roberge
Recruiting
Jewish General Hospital
Montreal, Quebec, Canada
Thierry M. Muanza
Recruiting
the Research Institute of the Mcgill University Health Centre (muhc)
Montreal, Quebec, Canada
Suspended
Chu de Quebec-L'Hotel-Dieu de Quebec (hdq)
Québec, Quebec, Canada
Isabelle Thibault
Recruiting
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada
Suspended

United States

University of Arizona Cancer Center-North Campus
Tucson, Arizona, United States
Baldassarre Stea
Recruiting
University of Arizona Cancer Center-Orange Grove Campus
Tucson, Arizona, United States
Baldassarre Stea
Recruiting
City of Hope Corona
Corona, California, United States
Sean Szeja
Recruiting
City of Hope Comprehensive Cancer Center
Duarte, California, United States
Sean Szeja
Recruiting
City of Hope at Irvine Lennar
Irvine, California, United States
Sean Szeja
Recruiting
Uc San Diego Moores Cancer Center
La Jolla, California, United States
Suspended
City of Hope Antelope Valley
Lancaster, California, United States
Sean Szeja
Recruiting
Uc Irvine Health/chao Family Comprehensive Cancer Center
Orange, California, United States
Active, not recruiting
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California, United States
Active, not recruiting
Rohnert Park Cancer Center
Rohnert Park, California, United States
Active, not recruiting
the Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, United States
Active, not recruiting
South Sacramento Cancer Center
Sacramento, California, United States
Active, not recruiting
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States
Active, not recruiting
City of Hope South Pasadena
South Pasadena, California, United States
Sean Szeja
Recruiting
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, United States
Active, not recruiting
City of Hope South Bay
Torrance, California, United States
Sean Szeja
Recruiting
City of Hope Upland
Upland, California, United States
Sean Szeja
Recruiting
Boca Raton Regional Hospital
Boca Raton, Florida, United States
Active, not recruiting
Um Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States
Benjamin J. Rich
Recruiting
Um Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States
Benjamin J. Rich
Recruiting
Memorial Regional Hospital/joe Dimaggio Children'S Hospital
Hollywood, Florida, United States
Active, not recruiting
Mayo Clinic in Florida
Jacksonville, Florida, United States
Active, not recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Benjamin J. Rich
Recruiting
Memorial Hospital West
Pembroke Pines, Florida, United States
Active, not recruiting
Um Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, United States
Benjamin J. Rich
Recruiting
Moffitt Cancer Center
Tampa, Florida, United States
Active, not recruiting
Emory Saint Joseph'S Hospital
Atlanta, Georgia, United States
Suspended

46 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Memantine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 Nov 2018
Primary completion: 30 Jun 2027
Completion: 31 Dec 2027
Last update posted: 9 Jun 2026
Registered enrollment: 206
Registry id: NCT03550391

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.