Clinical trialNCT03560232TerminatedPhase 4Interventional

Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens

SponsorMercy Health OhioEnrollment17Open FracturePost-Op Wound Infection

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

To demonstrate noninferiority of three different empiric antimicrobial regimens compared to the traditional antimicrobial regimen for the management of grade III open fractures as well as evaluate outcomes among these groups.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Allison R Lauver, PharmD
MercyHealth Youngstown
Study Chair
clinicaltrials.gov ↗
Chad W Donley, MD
MercyHealth Youngstown
Principal Investigator
clinicaltrials.gov ↗
David J Gemmel, PhD
MercyHealth Youngstown
Study Chair
clinicaltrials.gov ↗
Natalie I Rine, PharmD
MercyHealth Youngstown
Study Chair
clinicaltrials.gov ↗
Paul T Miller, PharmD
MercyHealth Youngstown
Study Chair
clinicaltrials.gov ↗
Stuart Drew, DO
MercyHealth Youngstown
Study Chair
clinicaltrials.gov ↗
Tyson T Schrickel, MD
MercyHealth Youngstown
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

St. Joseph Warren Hospital
Warren, Ohio, United States
St. Elizabeth Youngstown Hospital
Youngstown, Ohio, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Ampicillin / sulbactamCefazolin + GentamicinCeftriaxone →Clindamycin + GentamicinPiperacillin / tazobactam

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 9 Jul 2018
Primary completion: 19 Feb 2020
Completion: 19 Feb 2020
Last update posted: 11 Sept 2020
Registered enrollment: 17
Registry id: NCT03560232

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.