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Clinical trialNCT03625453CompletedPhase 2Interventional

Study of ABX-1431 in Adult Patients With Tourette Syndrome or Chronic Motor Tic Disorder

SponsorAbide TherapeuticsEnrollment50Motor Tic DisorderTourette Syndrome
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Two-part study consisting of a double-blind, randomized, placebo-controlled, study at two target dose levels (Part 1) and an open-label, non-randomized study (Part 2) to determine the efficacy of ABX-1431 in treating adult patients with Tourette syndrome or Chronic Motor Tic Disorder as measured by the change from baseline in Total Tic Score of the Yale Global Tic Severity Scale (YGTSS-TTS) compared with placebo.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Germany
  • Charité, Universitätsmedizin Berlin, Klinik Für Neurologie Mit Experimenteller Neurologie

    Berlin, Germany

  • Uniklinik Köln, Klinik Für Psychiatrie Und Psychotherapie

    Cologne, Germany

  • Medizinische Hochschule Hannover (mhh), Klinik Für Psychiatrie, Sozialpsychiatrie Und Psychotherapie

    Hanover, Germany

  • Universität Zu Lübeck, Cbbm / Institut Für Neurogenetik

    Lübeck, Germany

  • Lmu Klinikum Der Universität München, Klinik Für Psychiatrie Und Psychotherapie

    München, Germany

Poland
  • Centrum Medyczne Damiana Holding Sp Zo.O.

    Warsaw, Poland

Spain
  • Complejo Hospitalario Regional Virgen del Rocío

    Seville, Andalusia, Spain

  • Complejo Hospitalario Gregorio Marañón

    Madrid, Spain

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

ABX-1431Placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
15 Oct 2018
Primary completion
20 Jan 2020
Completion
20 Jan 2020
Last update posted
8 Apr 2020
Registered enrollment
50
Registry id
NCT03625453

Cross-registrations

EU-CTR / CTIS (EudraCT)2018-000100-41
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.