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Clinical trialNCT03627715CompletedPhase 2Interventional

Safety and Effectiveness of Propagermanium in Diabetic Kidney Disease Participants Receiving Irbesartan

SponsorDimerix Bioscience Pty LtdEnrollment45Diabetic Kidney Disease
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study will be evaluating the safety and efficacy of propagermanium for the treatment of participants with DKD who are already taking irbesartan by: * monitoring symptoms that participants may experience while on the study, * measuring levels of protein in participant's urine and kidney function during the course of the study, * measuring the levels of propagermanium and irbesartan that enters into participant's urine and blood, and * comparing the propagermanium outcomes to participants' pre-study and placebo outcomes. Eligible participants will randomly be assigned to one of two arms to receive both the propagermanium and placebo in different orders as follows, either: Treatment Period 1 taking a propagermanium capsule twice a day for 12 weeks, followed by a six week washout period followed by Treatment Period 2 taking a placebo capsule twice a day for 12 weeks. OR Treatment Period 1 taking a placebo capsule twice a day for 12 weeks, followed by a six week washout period followed by Treatment Period 2 taking a propagermanium capsule twice a day for 12 weeks.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Renal Research

    Gosford, New South Wales, Australia

  • Liverpool Hospital

    Liverpool, New South Wales, Australia

  • Royal North Shore Hospital

    St Leonards, New South Wales, Australia

  • Westmead Hospital

    Westmead, New South Wales, Australia

  • Sunshine Coast University Hospital

    Birtinya, Queensland, Australia

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, Australia

  • Boxhill Hospital

    Box Hill, Victoria, Australia

  • Austin Hospital

    Heidelberg, Victoria, Australia

  • Melbourne Renal Research Group

    Melbourne, Victoria, Australia

  • Royal Melbourne Hospital

    Melbourne, Victoria, Australia

  • St Vincents Hospital

    Melbourne, Victoria, Australia

  • Sunshine Hospital

    Melbourne, Victoria, Australia

  • Epworth Hospital

    Richmond, Victoria, Australia

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboProxigermanium
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
6 Nov 2018
Primary completion
23 Jul 2020
Completion
18 Aug 2020
Last update posted
29 Jul 2022
Registered enrollment
45
Registry id
NCT03627715

Cross-registrations

ANZCTR (AU/NZ)ACTRN12618000982213p

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.