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Clinical trialNCT03635788Active, not recruitingPhase 3Interventional

The LATITUDE Study: Long-Acting Therapy to Improve Treatment SUccess in Daily LifE

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment456HIV Infections
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study was to compare the efficacy, safety, and durability of two different strategies to treat participants with a history of sub-optimal adherence and control of their HIV infection: long-acting (LA) antiretroviral therapy (ART) and all-oral standard of care (SOC).

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

33 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico
  • Puerto Rico Aids Clinical Trials Unit Crs

    San Juan, Puerto Rico

United States
  • Alabama Crs

    Birmingham, Alabama, United States

  • Ucla Care Center Crs

    Los Angeles, California, United States

  • University of Southern California Crs

    Los Angeles, California, United States

  • Ucsd Antiviral Research Center Crs

    San Diego, California, United States

  • Ucsf Hiv/aids Crs

    San Francisco, California, United States

  • Harbor-Ucla Crs

    Torrance, California, United States

  • University of Colorado Hospital Crs

    Aurora, Colorado, United States

  • Univ. of Florida Jacksonville Nichd Crs

    Jacksonville, Florida, United States

  • the Ponce de Leon Center Crs

    Atlanta, Georgia, United States

  • Northwestern University Crs

    Chicago, Illinois, United States

  • Rush University Crs

    Chicago, Illinois, United States

  • Johns Hopkins University Crs

    Baltimore, Maryland, United States

  • Brigham and Women'S Hospital Therapeutics Clinical Research Site (bwh Tcrs) Crs

    Boston, Massachusetts, United States

  • Massachusetts General Hospital Crs (mgh Crs)

    Boston, Massachusetts, United States

  • Washington University Therapeutics (wt) Crs

    St Louis, Missouri, United States

  • New Jersey Medical School Clinical Research Center Crs

    Newark, New Jersey, United States

  • Columbia P&s Crs

    New York, New York, United States

  • Weill Cornell Chelsea Crs

    New York, New York, United States

  • Weill Cornell Uptown Crs

    New York, New York, United States

  • Suny Stony Brook Nichd Crs

    Stony Brook, New York, United States

  • Jacobi Med. Ctr. Bronx Nichd Crs

    The Bronx, New York, United States

  • Chapel Hill Crs

    Chapel Hill, North Carolina, United States

  • Greensboro Crs

    Greensboro, North Carolina, United States

  • Cincinnati Clinical Research Site

    Cincinnati, Ohio, United States

  • Case Clinical Research Site

    Cleveland, Ohio, United States

  • Ohio State University Crs

    Columbus, Ohio, United States

  • Penn Therapeutics, Crs

    Philadelphia, Pennsylvania, United States

  • University of Pittsburgh Crs

    Pittsburgh, Pennsylvania, United States

  • the Miriam Hospital Clinical Research Site (tmh Crs) Crs

    Providence, Rhode Island, United States

  • Vanderbilt Therapeutics (vt) Crs

    Nashville, Tennessee, United States

  • Houston Aids Research Team Crs

    Houston, Texas, United States

  • University of Washington Aids Crs

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CAB-LA Loading DoseCAB-LA Maintenance DoseOral CABOral RPVRPV-LA Loading DoseRPV-LA Maintenance DoseStandard of Care Oral ART
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
28 Mar 2019
Primary completion
12 Feb 2024
Completion
30 Aug 2026
Last update posted
24 Jun 2026
Registered enrollment
456
Registry id
NCT03635788

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.