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Clinical trialNCT03680560TerminatedPhase 1Interventional

Study of ACTR T Cell Product in Combination With Trastuzumab in Subjects With HER2-Positive Advanced Solid Tumor Cancers

SponsorCogent Biosciences, Inc.Enrollment6HER-2 Protein OverexpressionSolid Tumor
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a Phase 1, open-label, multi-center study to assess safety and determine the recommended phase 2 dose (RP2D) of ACTR T cell product (ACTR707 or ACTR087) in combination with trastuzumab, following lymphodepleting chemotherapy in subjects with HER2-positive advanced malignancies.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Yale Smilow Cancer Hospital

    New Haven, Connecticut, United States

  • Miami University Cancer Center

    Miami, Florida, United States

  • the Ohio State University

    Columbus, Ohio, United States

  • Sarah Cannon Research Institute/tennessee Oncology, Pllc

    Nashville, Tennessee, United States

  • Baylor Scott & White Medical Center

    Dallas, Texas, United States

  • Md Anderson Cancer Center

    Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

ACTR T Cell ProductTrastuzumab →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
13 Mar 2019
Primary completion
12 Mar 2020
Completion
12 Mar 2020
Last update posted
31 Mar 2020
Registered enrollment
6
Registry id
NCT03680560

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.