FindMyKOL
Clinical trialNCT03740529CompletedPhase 1/PHASE2Interventional

A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHL

SponsorLoxo Oncology, Inc.Enrollment803B-cell LymphomaChronic Lymphocytic LeukemiaMantle Cell LymphomaMarginal Zone LymphomaSmall Lymphocytic LymphomaWaldenstrom Macroglobulinemia
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is an open-label, multi-center Phase 1/2 study of oral LOXO-305 (pirtobrutinib) in patients with CLL/SLL and NHL who have failed or are intolerant to standard of care.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

56 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Flinders Medical Centre

    Bedford Park, South Australia, Australia

  • Peter Maccallum Cancer Centre

    Melbourne, Victoria, Australia

  • Linear Clinical Research

    Nedlands, Western Australia, Australia

France
  • Centre Hospitalier Universitaire de Nantes - L' Hopital L'Hôtel-Dieu

    Nantes, France

Italy
  • Irccs - Aou Di Bologna

    Bologna, Italy

  • Irccs Ospedale San Raffaele

    Milan, Italy

Japan
  • Nagoya Medical Center

    Nagoya, Aichi-ken, Japan

  • Hokkaido University Hospital

    Sapporo, Hokkaido, Japan

  • Tokai University Hospital- Isehara Campus

    Isehara, Kanagawa, Japan

  • Kochi Medical School Hospital

    Nankoku, Kochi, Japan

  • Tohoku University Hospital

    Sendai, Miyagi, Japan

  • National Cancer Center Hospital

    Chuo Ku, Tokyo, Japan

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, Japan

  • Kyoto Furitsu Medical University Hospital

    Kyoto, Japan

  • Okayama University Hospital

    Okayama, Japan

  • Kindai University Hospital

    Osakasayama-Shi, Japan

Poland
  • Pratia Mcm Krakow

    Krakow, Poland

  • Instytut Hermatologii I Transfuzjologii

    Warsaw, Poland

South Korea
  • Samsung Medical Center

    Seoul, Seoul-teukbyeolsi [Seoul], South Korea

  • Seoul National University Hospital

    Seoul, South Korea

Sweden
  • Karolinska Institutet

    Solna, AB, Sweden

Switzerland
  • Ospedale Regionale Bellinzona E Valli

    Bellinzona, Canton Ticino, Switzerland

United Kingdom
  • St James'S University Hospital

    Leeds, United Kingdom

  • Churchill Hospital

    Oxford, United Kingdom

  • Derriford Hospital

    Plymouth, United Kingdom

United States
  • Mayo Clinic of Scottsdale

    Scottsdale, Arizona, United States

  • Scripps Coastal Medical Center

    San Diego, California, United States

  • University of California San Francisco, Medical Center at Paranassus

    San Francisco, California, United States

  • Smilow Cancer Hospital at Yale-New Haven

    New Haven, Connecticut, United States

  • Mayo Clinic-Jacksonville

    Jacksonville, Florida, United States

  • Florida Cancer Specialists Orlando/ddu

    Lake Mary, Florida, United States

  • Sylvester Comprehensive Cancer Center

    Miami, Florida, United States

  • Florida Cancer Specialists

    Sarasota, Florida, United States

  • Emory Clinic

    Atlanta, Georgia, United States

  • Northwestern University

    Chicago, Illinois, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, United States

  • Mayo Clinic

    Rochester, Minnesota, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, United States

16 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
15 Mar 2019
Primary completion
27 Jan 2025
Completion
23 Dec 2025
Last update posted
27 Jan 2026
Registered enrollment
803
Registry id
NCT03740529

Cross-registrations

EU-CTR / CTIS (EudraCT)2018-003340-24

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.