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Clinical trialNCT03745131CompletedObservational

Cohort Study of Healthcare Workers Receiving Imvanex®

SponsorPublic Health EnglandEnrollment120Monkeypox
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

During an outbreak of monkeypox in the UK in 2018, a third generation smallpox vaccine, Imvanex, was used for the first time to immunise healthcare workers who had been, or were expected to be, in contact with cases of monkeypox. This study will examine the antibody responses in these healthcare workers compared to control groups, to provide evidence that the vaccine can produce a response consistent with protection when used in this context.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United Kingdom
  • Blackpool Teaching Hospitals Nhs Foundation Trust

    Blackpool, Lancashire, United Kingdom

  • Royal Liverpool and Broadgreen University Hospitals Nhs Trust

    Liverpool, Merseyside, United Kingdom

  • Newcastle Hospitals Nhs Foundation Trust

    Newcastle upon Tyne, Tyne and Wear, United Kingdom

  • Guy'S and St Thomas' Nhs Foundation Trust

    London, United Kingdom

  • Royal Free London Nhs Foundation Trust

    London, United Kingdom

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Oct 2018
Primary completion
30 May 2019
Completion
30 Nov 2019
Last update posted
3 Mar 2020
Registered enrollment
120
Registry id
NCT03745131
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.