Clinical trialNCT03754114Active, not recruitingInterventional

Brain Oxygen Optimization in Severe TBI, Phase 3

SponsorUniversity of MichiganEnrollment1,094Brain Injuries, Traumatic

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and efficacy of a strategy guided by treatment goals based on both intracranial pressure (ICP) and brain tissue oxygen (PbtO2) as compared to a strategy guided by treatment goals based on ICP monitoring alone. Both of these alternative strategies are used in standard care. It is unknown if one is more effective than the other. In both strategies the monitoring and goals help doctors adjust treatments including the kinds and doses of medications and the amount of intravenous fluids given, ventilator (breathing machine) settings, need for blood transfusions, and other medical care. The results of this study will help doctors discover if one of these methods is more safe and effective.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Lori Shutter, MD
University of Pittsburgh, Pittsburgh, PA 15260
Principal Investigator
clinicaltrials.gov ↗
Ramon Diaz-Arrastia, MD, PhD
University of Pennsylvania, Philadelphia, PA 19104
Principal Investigator
clinicaltrials.gov ↗
Sharon Yeatts, PhD
Medical University of South Carolina, Charleston, SC 29425
Principal Investigator
clinicaltrials.gov ↗
William Barsan, MD
University of Michigan, Ann Arbor, MI 48109
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

51 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

University of Calgary - Foothills Medical Centre
Calgary, Alberta, Canada
St. Michaels Hospital
Toronto, Ontario, Canada
Ciusss-Nim Hopital Du Sacre - Coeur de Montreal
Montreal, Canada

United States

Cedars-Sinai Medical Center
Los Angeles, California, United States
Ronald Reagan Ucla Medical Center
Los Angeles, California, United States
Stanford University Medical Center
Palo Alto, California, United States
Uc Davis Medical Center
Sacramento, California, United States
San Francisco General Hospital
San Francisco, California, United States
University of Colorado Hospital
Aurora, Colorado, United States
Yale New Haven Hospital
New Haven, Connecticut, United States
Uf Health Shands Hospital
Gainesville, Florida, United States
Grady Memorial Hospital
Atlanta, Georgia, United States
the Queen'S Medical Center
Honolulu, Hawaii, United States
University of Chicago Medical Center
Chicago, Illinois, United States
St. Vincent Hospital
Indianapolis, Indiana, United States
Maine Medical Center
Portland, Maine, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
University of Maryland Medical Center
Baltimore, Maryland, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Brigham and Women'S Hospital
Boston, Massachusetts, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Umass Memorial Medical Center
Worcester, Massachusetts, United States
University of Michigan
Ann Arbor, Michigan, United States
Detroit Receiving Hospital
Detroit, Michigan, United States
Henry Ford Hospital
Detroit, Michigan, United States
Regions Hospital
Saint Paul, Minnesota, United States
Cooper University Hospital
Camden, New Jersey, United States
University of New Mexico Hospital
Albuquerque, New Mexico, United States
Newyork-Presbyterian Queens Hospital
Flushing, New York, United States
North Shore University Hospital
Manhasset, New York, United States
Nyp Columbia University Medical Center
New York, New York, United States
Strong Memorial Hospital
Rochester, New York, United States
Suny Upstate Medical University
Syracuse, New York, United States
Jacobi Medical Center
The Bronx, New York, United States
University of North Carolina Medical Center
Chapel Hill, North Carolina, United States
Duke University Hospital
Durham, North Carolina, United States
University of Cincinnati Medical Center
Cincinnati, Ohio, United States
Osu Wexner Medical Center
Columbus, Ohio, United States
Riverside Methodist Hospital
Columbus, Ohio, United States
Oregon Health & Science University Hospital
Portland, Oregon, United States

11 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 28 Aug 2019
Primary completion: 1 Nov 2027
Completion: 1 Nov 2027
Last update posted: 5 May 2026
Registered enrollment: 1,094
Registry id: NCT03754114

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.