Clinical trialNCT03759522RecruitingPhase 1Interventional

Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

SponsorUniversity of Alabama at BirminghamEnrollment120Chronic Fatigue SyndromeFibromyalgiaHealthyMultiple Sclerosis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical \[F-18\]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tracer \[F-18\]DPA-714 binds to the 18 kDa translocator protein (TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondria of activated microglia/macrophages and provides a non-invasive measure of neuroinflammation. The primary objective of this study is to determine if pain and fatigue patients have higher levels of neuroinflammation than HC individuals as measured with \[F-18\]DPA-714-PET/MRI.

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Investigators

No overall officials are registered on this study record. Site-level investigators, where published, appear with their sites below. Why? →

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham Medical Center
Birmingham, Alabama, United States
Bag Asim, MDBhambhvani Pradeep, MDChoudhary Gagandeep, MDGeldmacher David, MDJeffers Charlotte Denise, RPhJonathan McConathy, MD, PhDLapi Suzanne, PhDNatelson Marissa, MDRoberson Erik, MD, PhD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

DPA-714 PET/MRI

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 3 Feb 2019
Primary completion: 30 Apr 2028
Completion: 30 Apr 2028
Last update posted: 2 Jun 2026
Registered enrollment: 120
Registry id: NCT03759522

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.