Clinical trialNCT03779854RecruitingPhase 2Interventional

Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

SponsorFred Hutchinson Cancer CenterEnrollment68Acute Biphenotypic LeukemiaAcute LeukemiaAcute Leukemia of Ambiguous LineageAcute Lymphoblastic LeukemiaAcute Undifferentiated LeukemiaAllogeneic Hematopoietic Stem Cell Transplantation Recipient+11 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial studies how well naive T-cell depletion works in preventing chronic graft-versus-host disease in children and young adults with blood cancers undergoing donor stem cell transplant. Sometimes the transplanted white blood cells from a donor attack the body's normal tissues (called graft versus host disease). Removing a particular type of T cell (naive T cells) from the donor cells before the transplant may stop this from happening.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Marie Bleakley
Fred Hutch/University of Washington Cancer Consortium
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

10 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Children'S Hospital of Los Angeles
Los Angeles, California, United States
Ashley Gray
Recruiting
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Withdrawn
Children'S Healthcare of Atlanta
Atlanta, Georgia, United States
Benjamin Watkins
Not, yet, recruiting
University of Iowa/holden Comprehensive Cancer Center
Iowa City, Iowa, United States
Rajat Sharma
Recruiting
Dana Farber / Boston Children'S Hospital
Boston, Massachusetts, United States
Susanne Baumeister
Not, yet, recruiting
Cleveland Clinic Foundation
Cleveland, Ohio, United States
Completed
Uh Rainbow Babies and Children'S Hospital (university Hospitals Cleveland Medical Center)
Cleveland, Ohio, United States
Mari Dallas
Not, yet, recruiting
Oregon Health and Science University
Portland, Oregon, United States
Eneida Nemecek
Recruiting
Children'S Hospital of Pittsburgh of Upmc
Pittsburgh, Pennsylvania, United States
Jessie Barnum
Recruiting
Fred Hutch/university of Washington Cancer Consortium
Seattle, Washington, United States
Marie Bleakley
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Busulfan →Cyclophosphamide →Fludarabine →Methotrexate →Tacrolimus →Thiotepa

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Aug 2019
Primary completion: 31 Dec 2028
Completion: 31 Dec 2028
Last update posted: 29 Jul 2026
Registered enrollment: 68
Registry id: NCT03779854

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.