Clinical trialNCT03797495RecruitingObservational

Study of Individuals Affected With Hypoplasminogenemia

SponsorIndiana Hemophilia &Thrombosis Center, Inc.Enrollment100Plasminogen Deficiency

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is an Investigator initiated retrospective and prospective single cohort study. The study will utilize an international registry and develop a specimen biobank to provide an improved understanding of the natural history of hyposplasminogenemia, to elucidate the heterogeneity of phenotypic expression, identify markers to predict disease course, and inform improved therapeutic modalities

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Amy D Shapiro, MD
Indiana Hemophilia &Thrombosis Center, Inc.
Principal Investigator
clinicaltrials.gov ↗
Flora Peyvandi, MD, PhD
Univeristy of Milan
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

35 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

Hospital Britanico Buenos Aires
Buenos Aires, Argentina
Jhon A Avila, MDJose M Ceresetto, MD
Recruiting

Australia

Murdoch Children'S Research Institute, the Royal Children'S Hospital
Melbourne, Victoria, Australia
Paul Monagle, MD
Recruiting
Children'S Health Queensland Hospital and Health Service
South Brisbane, Australia
Sally Campbell, MD
Recruiting

Austria

Medical University of Innsbruck, University Clinic for Pediatrics and Adolescent Medicine
Innsbruck, Austria
Lukas Hackl, MD
Recruiting

Canada

Windsor Regional Hospital
Windsor, Ontario, Canada
Andrea Cervi, MD
Recruiting
Chu Sainte-Justine
Montreal, Quebec, Canada
Valerie Arsenault, MD
Recruiting
Chu de Québec Université Laval
Québec, Quebec, Canada
Marie-Claude Pelland-Marcotte, MD
Recruiting
University of Saskatchewan
Saskatoon, Canada
Sarah Tehseen, MBBS, MSc. FRCPC
Recruiting

Greece

Alexandra Hospital, Athens, Hematology Department
Athens, Greece
Vasiliki Gkalea, MD
Recruiting

Israel

Safra'S Children Hospital, Sheba Medical Center
Tel Aviv, Israel
Sarina Levy, MD
Recruiting

Italy

Angelo Bianchi Bonomi Hemophilia and Thrombosis Center,
Milan, Italy
Flora Peyvandi, MD,PhD
Recruiting
University Hospital of Padova
Padua, Italy
Maria Teresa Sartori, MD
Recruiting

Thailand

Faculty of Medicine, Chiang Mai University
Chiang Mai, Thailand
Rungrote Natesirinilkul, MD
Recruiting

Turkey (Türkiye)

Dokuz Eylul University Pediatric Pulmonology, Allergy and Clinical Immunology
Izmir, Balçova, Turkey (Türkiye)
Active, not recruiting
Uludag University, Medical Faculty Sebahattin Gazioğlu, Pediatric Hematology and Oncology Hospital
Bursa, Bursa, Turkey (Türkiye)
Yeter Düzenli Kar, MD
Recruiting
Ondokuz Mayıs Üniversitesi Tıp Fakültesi Pediatrik Hematoloji Bölümü
Samsun, Samsun, Turkey (Türkiye)
Canan Albayrak, MD
Recruiting
Istanbul University Cerrahpsasa, Cerrahpsasa Medical Faculty Pediatric Hematology and Oncology Department
Istanbul, Turkey (Türkiye)
Active, not recruiting
Istanbul Üniversitesi Onkoloji Enstitüsü
Istanbul, Turkey (Türkiye)
Basak Koc, MD
Recruiting
Yuzuncu Yil University Faculty of Medicine Department of Ophthalmology
Van, Turkey (Türkiye)
Muhammed Batur, MD
Recruiting

United Kingdom

Cardiff and Vale Uhb
Cardiff, Wales, United Kingdom
Deepan Gosrani, MD
Recruiting
Great Ormond Street Hospital for Children Nhs Foundation Trust
London, United Kingdom
Recruiting
Royal Free Hospital, Royal Free London Nhs Foundation Trust
London, United Kingdom
Pratima Chowdary, MD
Recruiting

United States

the University of Alabama (uab)
Birmingham, Alabama, United States
Christina Bemrich-Stolz, MD
Recruiting
Rush University Medical Center
Chicago, Illinois, United States
Mindy Simpson, MD
Recruiting
Indiana Hemophila @thrombosis Center
Indianapolis, Indiana, United States
Amy D Shapiro, MDCharles Nakar, MD
Recruiting
University of Minnesota, Pediatric Hem/onc & Cancer Survivorship Program
Minneapolis, Minnesota, United States
Alex Boucher, MD
Recruiting
Stony Brook University | Stony Brook Medicine
East Setauket, New York, United States
Nicole Muhlbauer, MD
Recruiting
Suny Upstate Medical University, Pediatric Hematology/oncology
Syracuse, New York, United States
Andrea Dvorak, MD
Recruiting
University of North Carolina at Chapel Hill
Raleigh, North Carolina, United States
Yasmina Abajas, MD
Recruiting
Wake Forest University
Winston-Salem, North Carolina, United States
Amanda Blair, MD
Recruiting
Hemophilia Center of Western Pennsylvania
Pittsburgh, Pennsylvania, United States
Recruiting
Vanderbilt Children'S Hematology-Oncology
Nashville, Tennessee, United States
Completed
Cook Children'S Medical Center
Forth Worth, Texas, United States
Marcela Torres, MD
Recruiting
the University of Texas Health Science Center at Houston
Houston, Texas, United States
Completed
Seattle Children'S Hospital
Seattle, Washington, United States
Gavin Roach, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 18 Dec 2018
Primary completion: 29 Jun 2029
Completion: 26 Nov 2029
Last update posted: 4 Jun 2026
Registered enrollment: 100
Registry id: NCT03797495

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.