Clinical trialNCT03801876RecruitingPhase 3Interventional

Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

SponsorNRG OncologyEnrollment300Clinical Stage I Esophageal Adenocarcinoma AJCC v8Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage II Esophageal Adenocarcinoma AJCC v8Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC v8Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8+7 more conditions

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Steven H Lin
NRG Oncology
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

96 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Mayo Clinic Hospital in Arizona
Phoenix, Arizona, United States
Active, not recruiting
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Active, not recruiting
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Fen Xia
Recruiting
Um Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States
William Jin
Recruiting
Um Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States
William Jin
Recruiting
Um Sylvester Comprehensive Cancer Center at Doral
Doral, Florida, United States
William Jin
Recruiting
Miami Cancer Institute
Miami, Florida, United States
Michael D. Chuong
Recruiting
Um Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, United States
William Jin
Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
William Jin
Recruiting
Orlando Health Cancer Institute
Orlando, Florida, United States
Active, not recruiting
Um Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, United States
William Jin
Recruiting
Emory Proton Therapy Center
Atlanta, Georgia, United States
Active, not recruiting
Emory Saint Joseph'S Hospital
Atlanta, Georgia, United States
Active, not recruiting
Emory University Hospital Midtown
Atlanta, Georgia, United States
Active, not recruiting
Emory University Hospital/winship Cancer Institute
Atlanta, Georgia, United States
Active, not recruiting
Alton Memorial Hospital
Alton, Illinois, United States
Active, not recruiting
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, United States
Neal D. Andruska
Recruiting
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, United States
Neal D. Andruska
Recruiting
Memorial Hospital East
Shiloh, Illinois, United States
Active, not recruiting
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States
Neal D. Andruska
Recruiting
Maryland Proton Treatment Center
Baltimore, Maryland, United States
Jason K. Molitoris
Recruiting
University of Maryland/greenebaum Cancer Center
Baltimore, Maryland, United States
Jason K. Molitoris
Recruiting
Um Upper Chesapeake Medical Center
Bel Air, Maryland, United States
Active, not recruiting
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, United States
Florence K. Keane
Recruiting
Mclaren Cancer Institute-Bay City
Bay City, Michigan, United States
Brian K. Yeh
Recruiting
Corewell Health Dearborn Hospital
Dearborn, Michigan, United States
John M. Robertson
Recruiting
Wayne State University/karmanos Cancer Institute
Detroit, Michigan, United States
Brian K. Yeh
Recruiting
Weisberg Cancer Treatment Center
Farmington Hills, Michigan, United States
Brian K. Yeh
Recruiting
Mclaren Cancer Institute-Flint
Flint, Michigan, United States
Brian K. Yeh
Recruiting
Karmanos Cancer Institute at Mclaren Greater Lansing
Lansing, Michigan, United States
Brian K. Yeh
Recruiting
Mclaren Cancer Institute-Lapeer Region
Lapeer, Michigan, United States
Brian K. Yeh
Recruiting
Mclaren Cancer Institute-Central Michigan
Mount Pleasant, Michigan, United States
Brian K. Yeh
Recruiting
Mclaren Cancer Institute-Owosso
Owosso, Michigan, United States
Brian K. Yeh
Recruiting
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan, United States
John M. Robertson
Recruiting
Corewell Health Beaumont Troy Hospital
Troy, Michigan, United States
John M. Robertson
Recruiting
Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota, United States
Completed
Mercy Hospital
Coon Rapids, Minnesota, United States
Charles Shideman
Recruiting
Unity Hospital
Fridley, Minnesota, United States
Active, not recruiting
Mayo Clinic Health Systems-Mankato
Mankato, Minnesota, United States
Completed
Minnesota Oncology Hematology Pa-Maplewood
Maplewood, Minnesota, United States
Charles Shideman
Recruiting

56 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 26 Jun 2019
Primary completion: 21 Dec 2026
Completion: 21 Dec 2031
Last update posted: 25 Jun 2026
Registered enrollment: 300
Registry id: NCT03801876

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.