Clinical trialNCT03809000Active, not recruitingPhase 2Interventional

A Study of Salvage Radiotherapy With or Without Enzalutamide in Recurrent Prostate Cancer Following Surgery

SponsorRTOG Foundation, Inc.Enrollment188Prostate Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Patients with post-prostatectomy PSA (Prostate Specific Antigen) recurrences with aggressive disease features will receive salvage radiation therapy and standard androgen deprivation therapy (ADT) or enhanced ADT to determine if there is any improvement in progression-free survival when enhanced ADT is used compared to standard ADT.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Edwin Posadas, MD
RTOG Foundation
Principal Investigator
clinicaltrials.gov ↗
Hiram Gay, MD
RTOG Foundation
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

108 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Chu de Quebec - L'Hotel-Dieu de Quebec
Québec, Quebec, Canada
Ciuss de L'Estrie - Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Canada

United States

Arizona Center for Cancer Care - Gilbert
Gilbert, Arizona, United States
Arizona Center for Cancer Care - Peoria
Peoria, Arizona, United States
Arizona Center for Cancer Care - Phoenix
Phoenix, Arizona, United States
Arizona Center for Cancer Care - Scottsdale East
Scottsdale, Arizona, United States
Arizona Center for Cancer Care - Scottsdale North
Scottsdale, Arizona, United States
Arizona Center for Cancer Care - Surprise
Surprise, Arizona, United States
Marin Cancer Care, Inc.
Greenbrae, California, United States
Marin Health Medical Center
Greenbrae, California, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
Usc Medical Center - Los Angeles County
Los Angeles, California, United States
University of Southern California
Los Angeles, California, United States
Roseville Radiation Oncology Center
Roseville, California, United States
Sutter Roseville Medical Center
Roseville, California, United States
Sutter Medical Center Sacramento
Sacramento, California, United States
University of California, San Francisco
San Francisco, California, United States
Valley View Hospital Cancer Center
Glenwood Springs, Colorado, United States
University of Florida Health Science Center
Gainesville, Florida, United States
Adventhealth Orlando
Orlando, Florida, United States
Moffitt Cancer Center
Tampa, Florida, United States
Nancy N. & J.C. Lewis Cancer & Research Pavilion
Savannah, Georgia, United States
Rush University Medical Center
Chicago, Illinois, United States
Decatur Memorial Hospital
Decatur, Illinois, United States
Crossroads Cancer Center
Effingham, Illinois, United States
Loyola University Medical Center
Maywood, Illinois, United States
University of Kansas Cancer Center
Kansas City, Kansas, United States
Kansas University Cancer Center Overland Park
Overland Park, Kansas, United States
Kansas University Cancer Center Westwood
Westwood, Kansas, United States
East Jefferson General Hospital
Metairie, Louisiana, United States
Lsu Healthcare Network/metairie Multi-Specialty Clinic
Metairie, Louisiana, United States
Coastal Cancer Treatment Center - Bath
Bath, Maine, United States
Waldo Count General Hospital - Belfast
Belfast, Maine, United States
Maine Health/smhc Cancer Care and Blood Disorders-Biddeford
Biddeford, Maine, United States
Maine Health/stephens Memorial - Norway
Norway, Maine, United States
Maine Medical Center - Bramhall S Portland
Portland, Maine, United States
Penobscot Bay Medical Center - Rockport
Rockport, Maine, United States
Maine Health Cc of York County - Sanford
Sanford, Maine, United States
Maine Health/smhcancer Care and Blood Disorders - Sanford
Sanford, Maine, United States
Maine Medical Cancer Center - Scarborough Campus
Scarborough, Maine, United States

68 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bicalutamide →Enzalutamide →GnRH analog

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 15 Apr 2019
Primary completion: 7 Apr 2023
Completion: 15 Sept 2029
Last update posted: 30 Dec 2025
Registered enrollment: 188
Registry id: NCT03809000

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.