Clinical trialNCT03817398Active, not recruitingPhase 2Interventional

Stopping Tyrosine Kinase Inhibitors in Affecting Treatment-Free Remission in Patients With Chronic Phase Chronic Myeloid Leukemia

SponsorChildren's Oncology GroupEnrollment110Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial studies how stopping tyrosine kinase inhibitors will affect treatment-free remission in patients with chronic myeloid leukemia in chronic phase. When the level of disease is very low, it's called molecular remission. TKIs are a type of medication that help keep this level low. However, after being in molecular remission for a specific amount of time, it may not be necessary to take tyrosine kinase inhibitors. It is not yet known whether stopping tyrosine kinase inhibitors will help patients with chronic myeloid leukemia in chronic phase continue or re-achieve molecular remission.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Sonali Chaudhury
Children's Oncology Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

173 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

John Hunter Children'S Hospital
Hunter Regional Mail Centre, New South Wales, Australia
the Children'S Hospital at Westmead
Westmead, New South Wales, Australia
Monash Medical Center-Clayton Campus
Clayton, Victoria, Australia
Royal Children'S Hospital
Parkville, Victoria, Australia
Perth Children'S Hospital
Perth, Western Australia, Australia

Canada

University of Alberta Hospital
Edmonton, Alberta, Canada
Cancercare Manitoba
Winnipeg, Manitoba, Canada
Iwk Health Centre
Halifax, Nova Scotia, Canada
Mcmaster Children'S Hospital at Hamilton Health Sciences
Hamilton, Ontario, Canada
Children'S Hospital
London, Ontario, Canada
Children'S Hospital of Eastern Ontario
Ottawa, Ontario, Canada
Hospital for Sick Children
Toronto, Ontario, Canada
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada
the Montreal Children'S Hospital of the Muhc
Montreal, Quebec, Canada
Chu de Quebec-Centre Hospitalier de L'Universite Laval (chul)
Québec, Canada

Puerto Rico

Hima San Pablo Oncologic Hospital
Caguas, Puerto Rico

United States

Children'S Hospital of Alabama
Birmingham, Alabama, United States
Usa Health Strada Patient Care Center
Mobile, Alabama, United States
Banner Children'S at Desert
Mesa, Arizona, United States
Banner University Medical Center - Tucson
Tucson, Arizona, United States
Arkansas Children'S Hospital
Little Rock, Arkansas, United States
Kaiser Permanente Downey Medical Center
Downey, California, United States
Miller Children'S and Women'S Hospital Long Beach
Long Beach, California, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
Children'S Hospital Los Angeles
Los Angeles, California, United States
Mattel Children'S Hospital Ucla
Los Angeles, California, United States
Valley Children'S Hospital
Madera, California, United States
Kaiser Permanente-Oakland
Oakland, California, United States
Ucsf Benioff Children'S Hospital Oakland
Oakland, California, United States
Children'S Hospital of Orange County
Orange, California, United States
Lucile Packard Children'S Hospital Stanford University
Palo Alto, California, United States
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Rady Children'S Hospital - San Diego
San Diego, California, United States
Children'S Hospital Colorado
Aurora, Colorado, United States
Rocky Mountain Hospital for Children-Presbyterian Saint Luke'S Medical Center
Denver, Colorado, United States
Connecticut Children'S Medical Center
Hartford, Connecticut, United States
Alfred I Dupont Hospital for Children
Wilmington, Delaware, United States
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Medstar Georgetown University Hospital
Washington D.C., District of Columbia, United States
Golisano Children'S Hospital of Southwest Florida
Fort Myers, Florida, United States

133 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Tyrosine Kinase Inhibitor

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 8 Nov 2019
Primary completion: 30 Sept 2026
Completion: 30 Sept 2026
Last update posted: 16 Jul 2026
Registered enrollment: 110
Registry id: NCT03817398

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.