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Clinical trialNCT03824483RecruitingPhase 2Interventional

Study of Zanubrutinib, Obinutuzumab, and Venetoclax in Patients With Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL)

SponsorMemorial Sloan Kettering Cancer CenterEnrollment230Chronic Lymphocytic Leukemia (CLL)Small Lymphocytic Leukemia (SLL)
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to determine the rate of minimum residual disease (MRD) negative response (i.e. the rate of no evidence of disease) of the study drugs, zanubrutinib, obinutuzumab, and venetoclax, given in combination as a treatment for CLL and/or SLL.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Northwestern University

    Evanston, Illinois, United States

    Recruiting
  • Massachusetts General Hospital (data Collection and Specimen Analysis)

    Boston, Massachusetts, United States

    Recruiting
  • Memorial Sloan Kettering at Basking Ridge

    Basking Ridge, New Jersey, United States

    Recruiting
  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, United States

    Recruiting
  • Memorial Sloan Kettering Commack

    Commack, New York, United States

    Recruiting
  • Memorial Sloan Kettering Westchester

    Harrison, New York, United States

    Recruiting
  • Memorial Sloan Kettering Cancer Center

    New York, New York, United States

    Recruiting
  • Memorial Sloan Kettering Nassau

    Uniondale, New York, United States

    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
22 Feb 2019
Primary completion
28 Feb 2027
Completion
28 Feb 2027
Last update posted
7 May 2026
Registered enrollment
230
Registry id
NCT03824483

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.