Clinical trialNCT03863470CompletedInterventional

Study of Therapeutic Exercise in Acute Respiratory Failure to Improve Neuromuscular Disability Trial

SponsorUniversity of PennsylvaniaEnrollment1,917Acute Respiratory FailureCritical Illness

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a stepped-wedge, cluster randomized, trial evaluating the effect of an early goal-directed mobilization intervention for ICU patients with acute respiratory failure within 12 medical and surgical ICUs across 4 hospitals in the University of Pennsylvania Health System. The investigators will conduct a 54-week trial to measure the effect of the intervention on multiple patient-centered outcomes of patient physical function and cognition, in addition to ICU and hospital length of stay and duration of mechanical ventilation compared to usual care.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Juliane Jablonski, DNP RN
University of Pennsylvania
Principal Investigator
clinicaltrials.gov ↗
Scott D Halpern, MD PhD
University of Pennsylvania School of Medicine - PAIR Center
Principal Investigator
clinicaltrials.gov ↗
William Schweickert, MD
University of Pennsylvania School of Medicine - Pulmonary, Allergy, and Critical Care
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, United States
Pennsylvania Hospital
Philadelphia, Pennsylvania, United States
Chester County Hospital
West Chester, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 4 Mar 2019
Primary completion: 15 Mar 2020
Completion: 30 Jul 2020
Last update posted: 21 Oct 2022
Registered enrollment: 1,917
Registry id: NCT03863470

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.