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Clinical trialNCT03872427Active, not recruitingPhase 2Interventional

Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study

SponsorNational Cancer Institute (NCI)Enrollment54Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmNF1 Mutation Positive Malignant Peripheral Nerve Sheath TumorUnresectable Malignant Solid Neoplasm
View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

31 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, United States

  • Um Sylvester Comprehensive Cancer Center at Aventura

    Aventura, Florida, United States

  • Um Sylvester Comprehensive Cancer Center at Coral Gables

    Coral Gables, Florida, United States

  • Um Sylvester Comprehensive Cancer Center at Deerfield Beach

    Deerfield Beach, Florida, United States

  • Um Sylvester Comprehensive Cancer Center at Kendall

    Miami, Florida, United States

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, United States

  • Um Sylvester Comprehensive Cancer Center at Plantation

    Plantation, Florida, United States

  • Moffitt Cancer Center

    Tampa, Florida, United States

  • Moffitt Cancer Center - Mckinley Campus

    Tampa, Florida, United States

  • Moffitt Cancer Center-International Plaza

    Tampa, Florida, United States

  • Northwestern University

    Chicago, Illinois, United States

  • University of Kansas Clinical Research Center

    Fairway, Kansas, United States

  • Haysmed

    Hays, Kansas, United States

  • University of Kansas Cancer Center

    Kansas City, Kansas, United States

  • the University of Kansas Cancer Center - Olathe

    Olathe, Kansas, United States

  • Mercy Hospital Pittsburg

    Pittsburg, Kansas, United States

  • Salina Regional Health Center

    Salina, Kansas, United States

  • University of Kansas Health System Saint Francis Campus

    Topeka, Kansas, United States

  • University of Kansas Hospital-Westwood Cancer Center

    Westwood, Kansas, United States

  • University of Kentucky/markey Cancer Center

    Lexington, Kentucky, United States

  • National Cancer Institute Developmental Therapeutics Clinic

    Bethesda, Maryland, United States

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, United States

  • University Health Truman Medical Center

    Kansas City, Missouri, United States

  • Laura and Isaac Perlmutter Cancer Center at Nyu Langone

    New York, New York, United States

  • Nyp/columbia University Medical Center/herbert Irving Comprehensive Cancer Center

    New York, New York, United States

  • Wake Forest University at Clemmons

    Clemmons, North Carolina, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, United States

  • University of Pittsburgh Cancer Institute (upci)

    Pittsburgh, Pennsylvania, United States

  • Ut Md Anderson Cancer Center

    Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Telaglenastat Hydrochloride
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
14 Dec 2019
Primary completion
30 Oct 2023
Completion
16 Apr 2027
Last update posted
17 Jun 2026
Registered enrollment
54
Registry id
NCT03872427

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.