Clinical trialNCT03896763Active, not recruitingInterventional

PROSpect: Prone and Oscillation Pediatric Clinical Trial

SponsorUniversity of PennsylvaniaEnrollment600Acute Respiratory Distress Syndrome in Children

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Severe pediatric acute respiratory distress syndrome (PARDS) is a life-threatening and frequent problem experienced by thousands of children each year. Little evidence supports current supportive practices during their critical illness. The overall objective of this study is to identify the best positional and/or ventilation practice that leads to improved patient outcomes in these critically ill children. We hypothesize that children with high moderate-severe PARDS treated with either prone positioning or high-frequency oscillatory ventilation (HFOV) will demonstrate more days off the ventilator when compared to children treated with supine positioning or conventional mechanical ventilation (CMV).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

David Wypij, PhD
Boston Children's Hospital
Principal Investigator
clinicaltrials.gov ↗
Ira M. Cheifetz, MD
UH Rainbow Babies and Children's Hospital
Principal Investigator
clinicaltrials.gov ↗
Martha AQ Curley, RN, PhD
University of Pennsylvania
Principal Investigator
clinicaltrials.gov ↗
Martin CJ Kneyber, MD, PhD
Beatrix Children's Hospital
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

49 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

Hospital de Pediatría J. P. Garrahan. Samic
Buenos Aires, Buenos Aires F.D., Argentina

Australia

Perth Children'S Hospital
Perth, Western Australia, Australia
Children'S Hospital at Westmead
Sydney, Australia

Brazil

Sabara Hospital Infantil
São Paulo, Brazil, Brazil
Hospital Sepaco
São Paulo, Brazil

Canada

Centre Hospitalier Universitaire Sainte Justine
Montreal, Quebec, Canada

Germany

Münster University Hospital
Münster, Germany

India

Rainbow Children'S Hospital
Hyderabad, India

Israel

Hadassah Medical Center
Jerusalem, Israel

Italy

Meyer Children'S Hospital
Florence, Italy, Italy
Bambino Gesu Children'S Hospital (area Rossa Unit)
Rome, Italy, Italy
Instituto Giannina Gasilini
Genova, Italy

Malaysia

University of Malaysia Medical Center
Kuala Lumpur, Malaysia

Netherlands

University Medical Center Groningen
Groningen, Netherlands

South Korea

Chonnam National University Hospital
Gwangju, South Korea

Thailand

Faculty of Medicine Ramathibodi Hospital
Bangkok, Thailand
Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok, Thailand
King Chulalongkorn Memorial Hospital
Bangkok, Thailand

United Arab Emirates

Shaikh Khalifa Medical City
Abu Dhabi, United Arab Emirates

United Kingdom

Birmingham Children'S Hospital
Birmingham, UK, United Kingdom
University Hospital Leicester Nhs Trust
Leicester, United Kingdom

United States

Children'S of Alabama
Birmingham, Alabama, United States
Banner Health
Phoenix, Arizona, United States
Arkansas Children'S Hospital
Little Rock, Arkansas, United States
Children'S Hospital Orange County
Orange, California, United States
Stanford Children'S Health
Palo Alto, California, United States
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, United States
Ann & Robert Lurie Children'S Hospital of Chicago
Chicago, Illinois, United States
Riley Hospital for Children at Iu Health
Indianapolis, Indiana, United States
University of Iowa Stead Family Chlldren'S Hospital
Iowa City, Iowa, United States
Norton Children'S Hospital
Louisville, Kentucky, United States
Bloomberg Children'S Center, Johns Hopkins University
Baltimore, Maryland, United States
Cs Mott Children'S Hospital
Ann Arbor, Michigan, United States
Children'S Hospital and Medical Center
Omaha, Nebraska, United States
Cohen Children'S Medical Center
Queens, New York, United States
Duke Children'S Hospital
Durham, North Carolina, United States
Uh Rainbow Babies & Children
Cleveland, Ohio, United States
Children'S Hospital at Oklahoma University Medical Center
Oklahoma City, Oklahoma, United States
Penn State Children'S Hospital
Hershey, Pennsylvania, United States
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States

9 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 May 2019
Primary completion: 13 Feb 2026
Completion: 31 Jan 2027
Last update posted: 5 May 2026
Registered enrollment: 600
Registry id: NCT03896763

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.