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Clinical trialNCT03904862TerminatedPhase 1/PHASE2Interventional

Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery

SponsorPediatric Brain Tumor ConsortiumEnrollment21MedulloblastomaMedulloblastoma RecurrentMedulloblastoma, Childhood
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multi center, Phase I, Phase II and surgical study of the CX-4945 drug (silmitasertib sodium) for patients with recurrent SHH (Sonic Hedgehog) medulloblastoma

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Children'S Hospital of Los Angeles

    Los Angeles, California, United States

  • Stanford University and Lucile Packard Children'S Hospital

    Palo Alto, California, United States

  • Children'S National Medical Center

    Washington D.C., District of Columbia, United States

  • University of Florida

    Gainesville, Florida, United States

  • Children'S Healthcare of Atlanta

    Atlanta, Georgia, United States

  • Ann & Robert H. Lurie Children'S Hospital of Chicago

    Chicago, Illinois, United States

  • Memorial Sloan-Kettering Cancer Center

    New York, New York, United States

  • Cincinnati Children'S Hospital Medical Center

    Cincinnati, Ohio, United States

  • Nationwide Children'S Hospital

    Columbus, Ohio, United States

  • Children'S Hospital of Pittsburgh of Upmc

    Pittsburgh, Pennsylvania, United States

  • St. Jude Children Research Hospital

    Memphis, Tennessee, United States

  • Baylor College of Medicine

    Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CX 4945
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
25 Jul 2019
Primary completion
11 Aug 2025
Completion
11 Aug 2025
Last update posted
30 Oct 2025
Registered enrollment
21
Registry id
NCT03904862

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.