Clinical trialNCT03937479CompletedPhase 2Interventional

Study Investigating the Effect of 4 Doses of RPL554 Given in Addition to Tiotropium to Patients With COPD

SponsorVerona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USAEnrollment416COPD

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to investigate the dose response of RPL554 in patients with moderate to severe CHRONIC OBSTRUCTIVE PULMONARY DISEASE that are still symptomatic despite treatment with a stable background of tiotropium over 4 weeks of treatment. This study is intended to support optimal dose selection for a Phase III program evaluating RPL554 as an add-on treatment to standard of care therapy.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Gary Ferguson
Pulmonary Research Institute of Southeast Michigan
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

50 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Pinnacle Research Group, Llc
Anniston, Alabama, United States
California Research Medical Group, Inc
Fullerton, California, United States
Southern California Institute for Respiratory Diseases, Inc.
Los Angeles, California, United States
Innovative Clinical Research
Lafayette, Colorado, United States
Meris Clinical Research
Brandon, Florida, United States
Clinical Research of West Florida
Clearwater, Florida, United States
Pulmonary Disease Specialists, Pa D/b/a Pds Research
Kissimmee, Florida, United States
Medical Research of Central Florida, Llc
Leesburg, Florida, United States
Clinical Trials of Florida, Llc
Miami, Florida, United States
Peninsula Research, Ormond Beach, Llc
Ormond Beach, Florida, United States
Medsol Clinical Research Center, Inc
Port Charlotte, Florida, United States
Progressive Medical Research
Port Orange, Florida, United States
Pasadena Center for Medical Research, Llc
St. Petersburg, Florida, United States
Florida Pulmonary Research Institute, Llc
Winter Park, Florida, United States
Columbus Regional Research Institute
Columbus, Georgia, United States
Vitalink Research - Hamilton Mill
Dacula, Georgia, United States
Vitalink Research - Duluth
Duluth, Georgia, United States
Gwinnett Biomedical Research
Lawrenceville, Georgia, United States
Iact Health
Rincon, Georgia, United States
Vitalink
Winder, Georgia, United States
Genesis Clinical Research and Consulting, Llc
Fall River, Massachusetts, United States
Pulmonary Research Institute of Southeast Michigan
Farmington Hills, Michigan, United States
Cities Research Center
Fridley, Minnesota, United States
American Health Research
Charlotte, North Carolina, United States
Clinical Research of Gastonia
Gastonia, North Carolina, United States
Research Carolina of Huntersville
Huntersville, North Carolina, United States
Clinical Research of Lake Norman
Mooresville, North Carolina, United States
New Horizons Clinical Research
Cincinnati, Ohio, United States
Aventiv Research, Inc
Columbus, Ohio, United States
Aventiv Research, Inc
Dublin, Ohio, United States
Crisor, Llc
Medford, Oregon, United States
Vitalink Research - Anderson
Anderson, South Carolina, United States
Lowcountry Lung and Critical Care, Pa
Charleston, South Carolina, United States
Vitalink-Columbia
Columbia, South Carolina, United States
Vitalink Research - Easley
Easley, South Carolina, United States
Piedmont Research Partners, Llc
Fort Mill, South Carolina, United States
Vitalink Research-Gaffney
Gaffney, South Carolina, United States
Vitalink Research-Greenville
Greenville, South Carolina, United States
Vitalink Research-Upstate
Greenville, South Carolina, United States
Clinical Research of Charleston
Mt. Pleasant, South Carolina, United States

10 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Ensifentrine 0.375 mg twice daily plus placebo, in addition to tiotropiumEnsifentrine 0.75 mg twice daily plus placebo, in addition to tiotropiumEnsifentrine 1.5 mg twice daily plus placebo, in addition to tiotropiumEnsifentrine 3.0 mg twice daily plus placebo, in addition to tiotropiumEnsifentrine placebo twice daily, in addition to tiotropium

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 May 2019
Primary completion: 15 Nov 2019
Completion: 15 Nov 2019
Last update posted: 20 Nov 2020
Registered enrollment: 416
Registry id: NCT03937479

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.