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Clinical trialNCT03955445RecruitingPhase 3Interventional

Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN

SponsorNovartis PharmaceuticalsEnrollment225C3 GlomerulopathyImmune-complex-membranoproliferative Glomerulonephritis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is an open-label extension study to evaluate the long-term efficacy, safety and tolerability of iptacopan in subjects with C3 glomerulopathy or idiopathic immune-complex-membranoproliferative glomerulonephritis

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

53 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina
  • Novartis Investigative Site

    CABA, Buenos Aires, Argentina

    Recruiting
  • Novartis Investigative Site

    Buenos Aires, Argentina

    Recruiting
Brazil
  • Novartis Investigative Site

    Belo Horizonte, Minas Gerais, Brazil

    Recruiting
  • Novartis Investigative Site

    Recife, Pernambuco, Brazil

    Recruiting
  • Novartis Investigative Site

    Porto Alegre, Rio Grande do Sul, Brazil

    Recruiting
  • Novartis Investigative Site

    Botucatu, São Paulo, Brazil

    Recruiting
  • Novartis Investigative Site

    São Paulo, São Paulo, Brazil

    Recruiting
  • Novartis Investigative Site

    Salvador, Brazil

    Recruiting
Canada
  • Novartis Investigative Site

    Toronto, Ontario, Canada

    Active, not recruiting
China
  • Novartis Investigative Site

    Beijing, China

    Recruiting
  • Novartis Investigative Site

    Shanghai, China

    Recruiting
Czechia
  • Novartis Investigative Site

    Prague, Czechia

    Active, not recruiting
France
  • Novartis Investigative Site

    Montpellier, France

    Recruiting
  • Novartis Investigative Site

    Paris, France

    Recruiting
  • Novartis Investigative Site

    Paris, France

    Active, not recruiting
  • Novartis Investigative Site

    Toulouse, France

    Recruiting
Germany
  • Novartis Investigative Site

    Erlangen, Germany

    Active, not recruiting
  • Novartis Investigative Site

    Essen, Germany

    Recruiting
  • Novartis Investigative Site

    Hamburg, Germany

    Active, not recruiting
  • Novartis Investigative Site

    Heidelberg, Germany

    Recruiting
  • Novartis Investigative Site

    Mainz, Germany

    Recruiting
Greece
  • Novartis Investigative Site

    Heraklion Crete., Greece

    Active, not recruiting
  • Novartis Investigative Site

    Thessaloniki, Greece

    Active, not recruiting
Israel
  • Novartis Investigative Site

    Petah Tikva, Israel

    Active, not recruiting
  • Novartis Investigative Site

    Petah Tikva, Israel

    Recruiting
Italy
  • Novartis Investigative Site

    Bari, BA, Italy

    Recruiting
  • Novartis Investigative Site

    Ranica, BG, Italy

    Recruiting
  • Novartis Investigative Site

    Roma, RM, Italy

    Recruiting
Japan
  • Novartis Investigative Site

    Nagoya, Aichi-ken, Japan

    Active, not recruiting
  • Novartis Investigative Site

    Asahikawa, Hokkaido, Japan

    Active, not recruiting
  • Novartis Investigative Site

    Sapporo, Hokkaido, Japan

    Completed
  • Novartis Investigative Site

    Takatsuki, Osaka, Japan

    Active, not recruiting
  • Novartis Investigative Site

    Ohtsu, Shiga, Japan

    Recruiting
  • Novartis Investigative Site

    Hachiōji, Tokyo, Japan

    Recruiting
  • Novartis Investigative Site

    Niigata, Japan

    Active, not recruiting
Netherlands
  • Novartis Investigative Site

    Leiden, South Holland, Netherlands

    Active, not recruiting
Spain
  • Novartis Investigative Site

    Pamplona, Navarre, Spain

    Recruiting
  • Novartis Investigative Site

    Barcelona, Spain

    Completed
  • Novartis Investigative Site

    Madrid, Spain

    Recruiting
  • Novartis Investigative Site

    Madrid, Spain

    Recruiting
13 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

LNP023
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
3 Oct 2019
Primary completion
30 May 2036
Completion
30 May 2036
Last update posted
7 Aug 2026
Registered enrollment
225
Registry id
NCT03955445

Cross-registrations

EU-CTR / CTIS (EudraCT)2018-004253-24EU-CTR / CTIS (EudraCT)2023-509343-27-00

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.