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Clinical trialNCT03973918TerminatedPhase 2Interventional

Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG

SponsorSidney Kimmel Comprehensive Cancer Center at Johns HopkinsEnrollment5Anaplastic AstrocytomaAnaplastic Pleomorphic XanthoastrocytomaBRAF V600EBRAF V600KGlioblastomaGliosarcoma+1 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this study is to estimate the efficacy of encorafenib and binimetinib as measured by radiographic response in recurrent high-grade primary brain tumors.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Uab Comprehensive Cancer Center

    Birmingham, Alabama, United States

  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    Baltimore, Maryland, United States

  • Wake Forest University Comprehensive Cancer Center

    Winston-Salem, North Carolina, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Binimetinib →Encorafenib →Research BloodsTumor Tissue
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
29 Jul 2019
Primary completion
30 Apr 2022
Completion
1 Oct 2023
Last update posted
31 Oct 2024
Registered enrollment
5
Registry id
NCT03973918
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.