Clinical trialNCT03982368CompletedPhase 2Interventional

A Study to Evaluate Safety and Efficacy of rhNGF Eye Solution vs Vehicle in Patients With Moderate to Severe Dry Eye

SponsorDompé Farmaceutici S.p.AEnrollment261Dry Eye Syndrome

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The objective of this study is to assess the efficacy and safety of rhNGF eye drops at 20 μg/ml concentration administered two or three times daily for 4 weeks in patients with moderate to severe dry eye.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Flavio Mantelli, MD, PhD
Dompé Farmaceutici SpA
Study Director
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William Lipsky, MD
Advanced Laser Vision Surgical Institute (Study Site) Intouch Clinical Research Center (SMO)
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Global Research Management
Glendale, California, United States
Eye Research Foundation
Newport Beach, California, United States
Martel Eye Medical Group
Rancho Cordova, California, United States
Sierra Clinical Trials & Research Organization
Santa Ana, California, United States
Clayton Eye Clinical Research, Llc
Morrow, Georgia, United States
Kentucky Eye Institute
Lexington, Kentucky, United States
Moyes Eye Center
Kansas City, Missouri, United States
Tauber Eye Center
Kansas City, Missouri, United States
Sightmd
Babylon, New York, United States
Toyos Clinic
Nashville, Tennessee, United States
Advanced Laser Vision Surgical Institute (study Site) Intouch Clinical Research Center (smo)
Houston, Texas, United States
Houston Eye Associates Hea - Gramercy Location
Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

RhNGF 20 μg/mlRhNGF 20 μg/ml + vehicle

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 10 Jun 2019
Primary completion: 15 Jul 2020
Completion: 15 Jul 2020
Last update posted: 19 Apr 2024
Registered enrollment: 261
Registry id: NCT03982368

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.