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Clinical trialNCT04001413WithdrawnPhase 2Interventional

Therapy for High-Risk HPV 16-Positive Oropharynx Cancer Patients

SponsorSidney Kimmel Comprehensive Cancer Center at Johns HopkinsEnrollment0HPV Positive Oropharyngeal Squamous Cell CarcinomaHPV-Related CarcinomaOropharynx Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Combination immune checkpoint inhibitor and DNA vaccine will result in clearance of HPV DNA biomarkers (oral and/or plasma) for patients with persistent HPV-16 E6/E7 DNA (HPV biomarker) after treatment with curative intent.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Johns Hopkins University

    Baltimore, Maryland, United States

  • Mount Sinai School of Medicine

    New York, New York, United States

  • Mount Sinai School of Medicine, the Tisch Cancer Institute

    New York, New York, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Durvalumab →MEDI0457
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
17 Sept 2019
Primary completion
25 Mar 2021
Completion
25 Mar 2021
Last update posted
29 Jul 2022
Registered enrollment
0
Registry id
NCT04001413
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.