Clinical trialNCT04029363RecruitingInterventional

Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk

SponsorHighLife SASEnrollment120Mitral Regurgitation

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

No overall officials are registered on this study record. Site-level investigators, where published, appear with their sites below. Why? →

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

50 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

St. Vincent'S Hospital - Sydney
Darlinghurst, New South Wales, Australia
David Muller, MD
Recruiting
John Hunter Hospital
Newcastle, New South Wales, Australia
Recruiting
Macquarie University Hospital
Sydney, New South Wales, Australia
Withdrawn
the Wesley Hospital
Auchenflower, Queensland, Australia
Sam Haymen, MD
Recruiting
St. Andrew'S Hospital
Adelaide, Australia
Joseph Montarello, MD
Recruiting
Princess Alexandra Hospital
Brisbane, Australia
Anthony Camuglia, MD
Recruiting
Warringal Hospital
Heidelberg, Australia
Terminated
the Alfred Hospital
Melbourne, Australia
Recruiting
John Hunter Hospital
Newcastle, Australia
Allan Davies
Recruiting
Mount Hospital
Perth, Australia
Wen Yeow, MD
Recruiting
North Shore Private Hospital
Sydney, Australia
Ravinay Bhinddi
Recruiting

Belgium

Zna Middelheim
Antwerp, Belgium
Pierfrancesco Agostoni, MD
Recruiting
Az Sint-Jan
Bruges, Belgium
Recruiting
Uz Leuven
Leuven, Belgium
Christophe Dubois, MD
Recruiting

France

Rangueil University Hospital
Toulouse, Toulouse, France
Recruiting
Chu Lille
Lille, France
Eric van Belle
Recruiting
Medipole Lyon-Villeurbanne
Lyon, France
Pierre-Yves Leroux, MD
Recruiting
Hopital Prive - Jacques Cartier
Massy, France
Thierry Lefevre
Recruiting
Centre Hospitalo-Universitaire de Nantes
Nantes, France
Vincent Letocart, MD
Recruiting
European Hospital George Pompidou
Paris, France
Terminated
Chu Bordeaux
Pessac, France
Recruiting
Chu de Rennes
Rennes, France
Recruiting
Centr Cardiologiqque Du Nord
Saint-Denis, France
Mohammed Nejjari
Recruiting
Chru Strasbourg
Strasbourg, France
Patrick Ohlmann, MD
Recruiting
Clinque Pasteur
Toulouse, France
Recruiting
Rangueil University Hospital
Toulouse, France
Lavie Badie, MD
Recruiting

Germany

University Heart Center Freiburg - Bad Krozingen
Bad Krozingen, Germany
Terminated
Universitaetsklinikum Bonn
Bonn, Germany
Georg Nickenig, MD
Recruiting
Heart Center, University Hospital Dresden
Dresden, Germany
Axel Linke
Recruiting
Mediinisches Versorgungszentrum
Hamburg, Germany
Joachim Schofer, MD
Recruiting
Universitatsklink Hamburg-Eppendorf
Hamburg, Germany
Niklas Schofer, MD
Recruiting
University Hospital Heidelberg
Heidelberg, Germany
Terminated
Herzentrum Leipzig
Leipzig, Germany
Tobias Kister, MD
Recruiting
Deutsches Herzzentrum Munchen
Munich, Germany
Michael Joner, MD
Recruiting
University Medicine Dept of Cardiology
Rostock, Germany
Terminated
University Hospital Ulm
Ulm, Germany
Wolfgang Rottbauer, MD
Recruiting

Poland

Medical University of Gdansk
Gdansk, Poland
Radoslaw Targonski, MD
Recruiting
Medical University of Silesia Hospital
Katowice, Poland
Wojciech Wojakowski, MD
Recruiting
University Hospital of Lord'S Transfiguration
Poznan, Poland
Terminated
Institute of Cardiology
Warsaw, Poland
Adam Witkowski, MD
Recruiting

10 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 28 May 2019
Primary completion: 15 Dec 2026
Completion: 15 Dec 2031
Last update posted: 15 Sept 2025
Registered enrollment: 120
Registry id: NCT04029363

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.