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Clinical trialNCT04066036CompletedObservational

Population Effectiveness of Dolutegravir Implementation in Sub-Saharan Africa

SponsorMassachusetts General HospitalEnrollment999HIV-1-infection
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a prospective observational cohort study enrolling participants in South Africa and Uganda who are prescribed an HIV treatment regimen containing lamivudine, tenofovir, and dolutegravir, which is known as TLD. We hope to better understand how effective TLD will be in sub-Saharan Africa. If treatment failure occurs, we seek to understand the possible reasons, including drug resistance and adherence challenges.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

  • Mark J Siedner, MD, MPH

    Massachusetts General Hospital, Africa Health Research Institute

    Principal Investigator
    clinicaltrials.gov ↗
  • Suzanne M McCluskey, MD

    Massachusetts General Hospital

    Principal Investigator
    clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

South Africa
  • Africa Health Research Institute

    Somkele, KwaZulu-Natal, South Africa

Uganda
  • Mbarara University of Science and Technology

    Mbarara, Uganda

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
14 May 2019
Primary completion
31 May 2023
Completion
31 May 2023
Last update posted
5 Aug 2026
Registered enrollment
999
Registry id
NCT04066036
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.