Clinical trialNCT04144972RecruitingInterventional

Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

SponsorUniversity of California, San FranciscoEnrollment12Complex Regional Pain SyndromesNerve InjuryNerve Root AvulsionPain, PostoperativePost Herpetic NeuralgiaPost Radiation Brain Injury+3 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target only brain regions involved in one aspect of the pain experience and provide continuous 24/7 brain stimulation which may lose effect over time. By developing new technology that targets multiple, complimentary brain regions in an adaptive fashion, the investigators will test a new therapy for chronic pain that has potential for better, more enduring analgesia.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Edward Chang, M.D.
University of California, San Francisco
Principal Investigator
clinicaltrials.gov ↗
Philip Starr, M.D., Ph.D.
University of California, San Francisco
Principal Investigator
clinicaltrials.gov ↗
Prasad Shirvalkar, M.D., Ph.D
University of California, San Francisco
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California, San Francisco
San Francisco, California, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 24 Oct 2019
Primary completion: 24 Oct 2029
Completion: 24 Oct 2030
Last update posted: 31 Jul 2026
Registered enrollment: 12
Registry id: NCT04144972

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.