Clinical trialNCT04177914RecruitingPhase 3Interventional

HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants

SponsorUniversity of UtahEnrollment176Hydrocephalus

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Hydrocephalus is a potentially debilitating neurological condition that primarily affects babies under a year of age and has traditionally been treated by inserting a shunt between the brain and the abdomen. A newer endoscopic procedure offers hope of shunt- free treatment that may reduce complications over a child's life, but it is not clear if the endoscopic procedure results in similar intellectual outcome as shunt. Therefore, the investigators propose a randomized trial to compare intellectual outcome and brain structural integrity between these two treatments, to help families make the best treatment decision for their baby.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Abhaya Kulkarni, MD
University of Toronto
Principal Investigator
clinicaltrials.gov ↗
David Limbrick, MD
Washington University School of Medicine
Principal Investigator
clinicaltrials.gov ↗
John Kestle, MD
University of Utah
Study Chair
clinicaltrials.gov ↗
Richard Holubkov, PhD
University of Utah
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

21 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Alberta Children'S Hospital
Calgary, Alberta, Canada
Jay Riva-Cambrin, MD
Recruiting
British Columbia Children'S Hospital
Vancouver, British Columbia, Canada
Mandeep Tamber, MD, PhD
Recruiting
the Hospital for Sick Children
Toronto, Ontario, Canada
Abhaya Kulkarni, MD, PhD
Recruiting

United States

Children'S of Alabama
Birmingham, Alabama, United States
Curtis Rozzelle, MD
Recruiting
Phoenix Children'S Hospital
Phoenix, Arizona, United States
Jason Hauptman
Not, yet, recruiting
Children'S Hospital of Los Angeles
Los Angeles, California, United States
Mark Krieger, MD
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Todd Hankinson, MD
Recruiting
Yale University
New Haven, Connecticut, United States
Active, not recruiting
Wolfson Children'S Hospital
Jacksonville, Florida, United States
Philipp R. Aldana, MD
Recruiting
Arnold Palmer Hospital for Children
Orlando, Florida, United States
Samer Elbabaa, MD
Recruiting
Trustees of Indiana University
Indianapolis, Indiana, United States
Jason Chu
Not, yet, recruiting
Johns Hopkins Children'S Center
Baltimore, Maryland, United States
Eric Jackson, MD
Recruiting
St. Louis Children'S Hospital
St Louis, Missouri, United States
Jennifer Strahle, MD, PhD
Recruiting
Nationwide Children'S Hospital
Columbus, Ohio, United States
Jonathan Pindrik, MD
Recruiting
Children'S Hospital of Pittsburgh of Upmc
Pittsburgh, Pennsylvania, United States
Ian Pollack, MD
Recruiting
the Pennsylvania State University
University Park, Pennsylvania, United States
Active, not recruiting
Monroe Carell Jr. Children'S Hospital at Vanderbilt
Nashville, Tennessee, United States
John C. Wellons, III, MD, MSPHRobert Naftel, MD
Recruiting
Texas Children'S Hospital
Houston, Texas, United States
William E. Whitehead, MD, MPH
Recruiting
Primary Children'S Hospital
Salt Lake City, Utah, United States
John Kestle, MD
Recruiting
Virginia Commonwealth University
Richmond, Virginia, United States
Active, not recruiting
Seattle Children'S Hospital
Seattle, Washington, United States
Hannah Goldstein, MDSamuel Browd, MD, PhD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 21 Jul 2020
Primary completion: 30 May 2027
Completion: 31 Aug 2027
Last update posted: 11 Jun 2025
Registered enrollment: 176
Registry id: NCT04177914

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.