Clinical trialNCT04217551CompletedInterventional

Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

SponsorUniversity of MichiganEnrollment1,158Cardiac Arrest, Out-Of-HospitalHypothermia, InducedHypoxia-Ischemia, Brain

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

A multicenter, randomized, adaptive allocation clinical trial to determine if increasing durations of induced hypothermia are associated with an increasing rate of good neurological outcomes and to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Robert Silbergleit
University of Michigan
Principal Investigator
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Romer Geocadin
Johns Hopkins University
Principal Investigator
clinicaltrials.gov ↗
William Meurer
University of Michigan
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

76 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama Hospital
Birmingham, Alabama, United States
Banner University Medical Center
Tucson, Arizona, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
Ronald Regan Ucla Medical Center
Los Angeles, California, United States
Uc Davis Medical Center
Sacramento, California, United States
Uc San Diego Medical Center - Hillcrest
San Diego, California, United States
Zuckerberg San Francisco General Hospital
San Francisco, California, United States
Stanford University Medical Center
Stanford, California, United States
Harbor-Ucla Medical Center
Torrance, California, United States
University of Colorado Hospital
Aurora, Colorado, United States
Denver Health Medical Center
Denver, Colorado, United States
Yale New Haven Hospital
New Haven, Connecticut, United States
George Washington University Hospital
Washington D.C., District of Columbia, United States
Uf Health Shands Hospital
Gainesville, Florida, United States
Grady Memorial Hospital
Atlanta, Georgia, United States
the Queen'S Medical Center
Honolulu, Hawaii, United States
Northwestern Memorial Hospital
Chicago, Illinois, United States
Rush University Medical Center
Chicago, Illinois, United States
University of Chicago Medical Center
Chicago, Illinois, United States
University of Illinois-Chicago Hosptial
Chicago, Illinois, United States
Advocate Christ Medical Center
Oak Lawn, Illinois, United States
Iu Health Methodist Hospital
Indianapolis, Indiana, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
University of Kentucky Hospital
Lexington, Kentucky, United States
Maine Medical Center
Portland, Maine, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
University of Maryland Medical Center
Baltimore, Maryland, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Brigham & Women'S Hospital
Boston, Massachusetts, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
University of Michigan Hospital
Ann Arbor, Michigan, United States
Henry Ford Macomb Hospital
Clinton Township, Michigan, United States
Dmc Sinai Grace Hospital
Detroit, Michigan, United States
Detroit Receiving Hospital
Detroit, Michigan, United States
Henry Ford Hospital
Detroit, Michigan, United States
William Beaumont Hospital
Royal Oak, Michigan, United States
M Health Fairview Southdale Hospital
Edina, Minnesota, United States
Hennepin County Medical Center
Minneapolis, Minnesota, United States
Regions Hospital
Saint Paul, Minnesota, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States

36 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 18 May 2020
Primary completion: 25 Aug 2025
Completion: 1 Feb 2026
Last update posted: 15 Jul 2026
Registered enrollment: 1,158
Registry id: NCT04217551

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.