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Clinical trialNCT04220229TerminatedPhase 1/PHASE2Interventional

Cabozantinib With Radiation Therapy for the Treatment of Sarcomas of the Extremities

SponsorUniversity of WashingtonEnrollment6Sarcoma of the ExtremityStage I Soft Tissue Sarcoma of the Trunk and ExtremitiesStage IA Soft Tissue Sarcoma of the Trunk and ExtremitiesStage IB Soft Tissue Sarcoma of the Trunk and ExtremitiesStage II Soft Tissue Sarcoma of the Trunk and Extremities
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase I/II trial studies the side effects and best dose of cabozantinib when given with radiation therapy and how well it works in treating patients with sarcoma of the extremities. Cabozantinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving cabozantinib with radiation therapy may make the tumors smaller and reduce the amount of normal tissue that needs to be removed.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • Lee Cranmer, MD, PhD

    Fred Hutch/University of Washington Cancer Consortium

    Principal Investigator
    clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Fred Hutch/university of Washington Cancer Consortium

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cabozantinib →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
1 Jun 2020
Primary completion
5 Apr 2024
Completion
31 Oct 2024
Last update posted
17 Jul 2025
Registered enrollment
6
Registry id
NCT04220229
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.