Clinical trialNCT04251052RecruitingInterventional

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

SponsorNRG OncologyEnrollment1,956Ovarian Carcinoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk reduction for women with BRCA1 mutations.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Kathryn P Pennington
NRG Oncology
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

574 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Bcca-Vancouver Cancer Centre
Vancouver, British Columbia, Canada
Janice S. Kwon
Recruiting
Chum - Centre Hospitalier de L'Universite de Montreal
Montreal, Quebec, Canada
Suspended

South Korea

Keimyung University-Dongsan Medical Center
Dalseo-gu, Daegu, South Korea
Suspended
Samsung Changwon Hospital
Seoul, Gyeongsangnam-do, South Korea
Suspended
Seoul National University Bundang Hospital
Seongnam, Kyeonggi-do, South Korea
Dong Hoon Suh
Recruiting
Chung-Ang University Gwangmyeong Hospital
Gwangmyeong, South Korea
Hyun Jin Choi
Recruiting
Asan Medical Center
Seoul, South Korea
Shin Wha Lee
Recruiting
Ewha Woman'S University Mokdong Hospital
Seoul, South Korea
Mikyung Kim
Recruiting
Gangnam Severance Hospital
Seoul, South Korea
Jae-Hoon Kim
Recruiting
Yonsei University Health System-Severance Hospital
Seoul, South Korea
Suspended

United States

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Charles A. Leath
Recruiting
Alaska Breast Care and Surgery Llc
Anchorage, Alaska, United States
Dan S. Zuckerman
Recruiting
Alaska Oncology and Hematology Llc
Anchorage, Alaska, United States
Dan S. Zuckerman
Recruiting
Alaska Women'S Cancer Care
Anchorage, Alaska, United States
Dan S. Zuckerman
Recruiting
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States
Dan S. Zuckerman
Recruiting
Anchorage Radiation Therapy Center
Anchorage, Alaska, United States
Suspended
Katmai Oncology Group
Anchorage, Alaska, United States
Dan S. Zuckerman
Recruiting
Providence Alaska Medical Center
Anchorage, Alaska, United States
Dan S. Zuckerman
Recruiting
Ctca at Western Regional Medical Center
Goodyear, Arizona, United States
Active, not recruiting
Banner University Medical Center - Tucson
Tucson, Arizona, United States
Setsuko K. Chambers
Recruiting
University of Arizona Cancer Center-North Campus
Tucson, Arizona, United States
Setsuko K. Chambers
Recruiting
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Heather R. Williams
Recruiting
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, United States
Christine Garcia
Recruiting
Tower Cancer Research Foundation
Beverly Hills, California, United States
Emily N. Prendergast
Recruiting
Keck Medicine of Usc Buena Park
Buena Park, California, United States
Koji Matsuo
Recruiting
Providence Saint Joseph Medical Center/disney Family Cancer Center
Burbank, California, United States
Dan S. Zuckerman
Recruiting
Mercy Cancer Center - Carmichael
Carmichael, California, United States
Shahzad Siddique
Recruiting
Mercy San Juan Medical Center
Carmichael, California, United States
Shahzad Siddique
Recruiting
City of Hope Comprehensive Cancer Center
Duarte, California, United States
Mihae Song
Recruiting
Kaiser Permanente Dublin
Dublin, California, United States
Christine Garcia
Recruiting
Mercy Cancer Center - Elk Grove
Elk Grove, California, United States
Shahzad Siddique
Recruiting
Kaiser Permanente-Fremont
Fremont, California, United States
Christine Garcia
Recruiting
Fresno Cancer Center
Fresno, California, United States
Suspended
Kaiser Permanente Fresno Orchard Plaza
Fresno, California, United States
Christine Garcia
Recruiting
Kaiser Permanente-Fresno
Fresno, California, United States
Christine Garcia
Recruiting
City of Hope Seacliff
Huntington Beach, California, United States
Mihae Song
Recruiting
Keck Medicine of Usc Huntington Beach
Huntington Beach, California, United States
Koji Matsuo
Recruiting
City of Hope at Irvine Lennar
Irvine, California, United States
Mihae Song
Recruiting
Kaiser Permanente-Irvine
Irvine, California, United States
Scott E. Lentz
Recruiting
City of Hope Antelope Valley
Lancaster, California, United States
Mihae Song
Recruiting

534 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Sept 2020
Primary completion: 30 Jun 2047
Completion: 30 Jun 2047
Last update posted: 7 Aug 2026
Registered enrollment: 1,956
Registry id: NCT04251052

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.