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Clinical trialNCT04283669CompletedPhase 2Interventional

Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas

SponsorUniversity of Alabama at BirminghamEnrollment12Neurofibromatosis 2Progressive Vestibular Schwannoma (VS)
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Subjects with Neurofibromatosis Type 2 (NF2) and progressive vestibular schwannoma (VS) will be treated with crizotinib administered orally. Crizotinib will be taken continuously until disease progression or unacceptable toxicity, in continuous treatment cycles of 28 days each, for a maximum of 12 cycles.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

15 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • the University of Alabama at Birmingham (site 700)

    Birmingham, Alabama, United States

  • Univ of California @ Los Angeles (site 325)

    Los Angeles, California, United States

  • Children's National Medical Center (site 775)

    Washington D.C., District of Columbia, United States

  • Children's Healthcare of Atlanta (site 950)

    Atlanta, Georgia, United States

  • Lurie Childrens Hospital of Chicago (site 350)

    Chicago, Illinois, United States

  • University of Chicago (site 850)

    Chicago, Illinois, United States

  • Indiana University (site 400)

    Indianapolis, Indiana, United States

  • Johns Hopkins University (site 250)

    Baltimore, Maryland, United States

  • Children's Hospital Boston (site 725)

    Boston, Massachusetts, United States

  • Washington University - St. Louis (site 900)

    St Louis, Missouri, United States

  • Memorial Sloan Kettering Cancer Center (site 210)

    New York, New York, United States

  • New York University Medical Center (site 200)

    New York, New York, United States

  • Cincinnati Children's Hospital Medical Center (site 800)

    Cincinnati, Ohio, United States

  • Children's Hospital of Philadelphia (site 750)

    Philadelphia, Pennsylvania, United States

  • Childrens Medical Center - Univ. of Texas Sw (site 917)

    Dallas, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
18 Feb 2020
Primary completion
25 Feb 2025
Completion
25 Feb 2025
Last update posted
13 Mar 2026
Registered enrollment
12
Registry id
NCT04283669

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.