findmyKOL
Clinical trialNCT04286438CompletedPhase 3Interventional

Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

SponsorSFJ Pharmaceuticals, Inc.Enrollment226HemorrhageInvasive ProcedureUrgent Surgery
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multi-center, open-label, prospective single-arm study of reversal of the antiplatelet effects of ticagrelor with bentracimab (PB2452) in patients who present with uncontrolled major or life-threatening bleeding or who require urgent surgery or invasive procedure. At least 200 patients will be enrolled from approximately 200 centers in North America, Europe, and Asia-Pacific regions, including mainland China. Patients with reported use of ticagrelor within the prior 3 days who require urgent ticagrelor reversal will be eligible for enrollment. These populations will be enrolled based on separate inclusion criteria.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

68 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Austria
  • Medical University of Graz

    Graz, STY, Austria

  • Klinische Abteilung Für Innere Medizin 3 Universitätsklinikum St. Pölten

    Sankt Pölten, Austria

  • Klinik Ottakring 3rd Med Dept, Cardiology and Intensive Care Medicine

    Vienna, Austria

Belgium
  • Algemeen Stedelijk Ziekenhuis (asz) Study Center Cardiology

    Aalst, East Flanders, Belgium

  • Ziekenhuis Oost-Limburg Study Center Intensive Care

    Genk, Limburg, Belgium

  • Az Sint-Jan Brugge-Oostende Av Poli Cardiologie

    Bruges, Belgium

  • University Hospital Antwerp Cardiology Department - Clinical Trials

    Edegem, Belgium

  • Jessa Hospital Hartcentrum Hasselt Research Center

    Hasselt, Belgium

Canada
  • Foothills Medical Centre

    Calgary, Alberta, Canada

  • Saint John Regional Hospital

    Saint John, New Brunswick, Canada

  • William Osler Health System

    Etobicoke, Ontario, Canada

  • Hamilton Health Sciences Centre

    Hamilton, Ontario, Canada

  • Kingston Health Science Centre

    Kingston, Ontario, Canada

  • York Pci Group, Inc.

    Newmarket, Ontario, Canada

  • St. Michael'S Hospital, Unity Health Toronto

    Toronto, Ontario, Canada

  • Toronto General Hospital

    Toronto, Ontario, Canada

  • Montreal Heart Institute

    Montreal, Quebec, Canada

China
  • Beijing Anzhen Hospital, Capital Medical University

    Beijing, Beijing Municipality, China

  • Peking University First Hospital

    Beijing, Beijing Municipality, China

  • Peking University People'S Hospital

    Beijing, Beijing Municipality, China

  • Peking University Third Hospital

    Beijing, Beijing Municipality, China

  • Lanzhou University Second Hospital

    Lanzhou, Gansu, China

  • Guizhou Provincial People'S Hospital

    Guiyang, Guizhou, China

  • the First Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, China

  • the First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, China

  • Renmin Hospital of Wuhan University

    Wuhan, Hubei, China

  • the Central Hospital of Wuhan

    Wuhan, Hubei, China

  • Huai'An First People'S Hospital

    Huai'an, Jiangsu, China

  • First Affiliated Hospital of Soochow University

    Suzhou, Jiangsu, China

  • the Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, China

  • the First Hospital of Jilin University

    Changchun, Jilin, China

  • the Second Affiliated Hospital of Jilin University

    Changchun, Jilin, China

  • General Hospital of Ningxia Medical University

    Yinchuan, Ningxia, China

  • Tianjin Chest Hospital

    Tianjin, Tianjin Municipality, China

  • Tianjin Medical University General Hospital

    Tianjin, Tianjin Municipality, China

  • Medidata

    Hangzhou, Zhejiang, China

  • Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, China

  • Shanghai General Hospital

    Shanghai, China

France
  • Chu de Lille Service Usic, Institut Coeur Poumon

    Lille, France

  • Assistance Publique-Hopitaux de Paris (ap-Hp) Pitie-Salpetriere Hospital

    Paris, France

28 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bentracimab Infusion
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
15 Jul 2020
Primary completion
9 Sept 2024
Completion
9 Sept 2024
Last update posted
21 Oct 2024
Registered enrollment
226
Registry id
NCT04286438

Cross-registrations

EU-CTR / CTIS (EudraCT)2019-004457-92
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.