Clinical trialNCT04312009CompletedPhase 2Interventional

Losartan for Patients With COVID-19 Requiring Hospitalization

SponsorUniversity of MinnesotaEnrollment205Acute Respiratory Distress SyndromeCorona Virus InfectionSARS-CoV Infection

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multi-center, double-blinded study of COVID-19 infected patients requiring inpatient hospital admission randomized 1:1 to daily Losartan or placebo for 7 days or hospital discharge.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Christopher Tignanelli, MD
University of Minnesota
Principal Investigator
clinicaltrials.gov ↗
Michael Puskarich, MD, MS
University of Minnesota
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Florida Health Gainesville
Gainesville, Florida, United States
University of Florida Health Jacksonville
Jacksonville, Florida, United States
Grady Memorial Hospital
Atlanta, Georgia, United States
Henry Ford Hospital
Detroit, Michigan, United States
M Health Fairview Ridges Hospital
Burnsville, Minnesota, United States
M Health Fairview Southdale Hospital
Edina, Minnesota, United States
Hennepin County Medical Center
Minneapolis, Minnesota, United States
M Health Fairview University of Minnesota Medical Center
Minneapolis, Minnesota, United States
University of Minnesota
Minneapolis, Minnesota, United States
North Memorial Health Hospital
Robbinsdale, Minnesota, United States
University of Mississippi Medical Center
Jackson, Mississippi, United States
Cooper University Hospital
Camden, New Jersey, United States
University of Cincinnati Medical Center
Cincinnati, Ohio, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Losartan →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 13 Apr 2020
Primary completion: 1 Feb 2021
Completion: 1 Feb 2021
Last update posted: 29 Jun 2022
Registered enrollment: 205
Registry id: NCT04312009

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.