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Clinical trialNCT04343287CompletedPhase 2/PHASE3Interventional

Safety and Efficacy of BRM421 for Dry Eye Syndrome Treatment

SponsorBRIM Biotechnology Inc.Enrollment220Dry Eye Syndrome
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The objective of this study is to compare the safety and efficacy of BRM421 Ophthalmic Solution to placebo for the treatment of the signs and symptoms of dry eye.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Eye Research Foundation

    Newport Beach, California, United States

  • Midwest Cornea Associates, Llc

    Indianapolis, Indiana, United States

  • Andover Eye Associates

    Andover, Massachusetts, United States

  • Total Eye Care

    Memphis, Tennessee, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

BRM421Placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
15 Jan 2020
Primary completion
23 Jun 2020
Completion
23 Jun 2020
Last update posted
1 May 2026
Registered enrollment
220
Registry id
NCT04343287

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.