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Clinical trialNCT04354064RecruitingObservational

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

SponsorWashington University School of MedicineEnrollment100Breast CancerColon CancerEsophageal CancerGastrointestinal CancerGenitourinary CancerHead and Neck Cancer+7 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes. This project is translational and has the potential to lead to future translational research opportunities, including interventional trials in which therapeutic escalation is offered at the early circulating tumor DNA (ctDNA) molecular residual disease (MRD) detection timepoint. Ultimately, the integration of ctDNA into the clinical workflow has the potential to enhance cancer diagnosis, treatment, surveillance, and prognosis, and guide clinical decision-making in this era of personalized precision medicine.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Washington University School of Medicine

    St Louis, Missouri, United States

    Angela Hirbe, M.D., Ph.D.Benjamin Tan, M.D.Brian Van Tine, M.D., Ph.D.Christopher Maher, Ph.D.Cynthia Ma, M.D., Ph.D.David Chen, M.D., Ph.D.Eric Kim, M.D.Ha Dang, Ph.D.Hiram Gay, M.D.Imran Zoberi, M.D.Jose Zevallos, M.D., MPHKoushik Das, M.D.Melissa Reimers, M.D.Nicholas Semenkovich, M.D., Ph.D.Paul Jones, B.A.Peter Harris, Ph.D.Re-I Chin, M.D.Ricardo Ramirez, M.D.Ryan Fields, M.D.Sidharth Puram, M.D., Ph.D.Varun Puri, M.D.Vivek Arora, M.D.Wade Thorstad, M.D.Zachary Smith, M.D.
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
29 May 2019
Primary completion
31 Dec 2026
Completion
31 Dec 2026
Last update posted
20 Feb 2026
Registered enrollment
100
Registry id
NCT04354064
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.