Clinical trialNCT04375332Active, not recruitingInterventional

Beating Heart Mitral Valve Repair With the HARPOON™ System

SponsorEdwards LifesciencesEnrollment25Mitral Regurgitation

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The objective of the study is to evaluate the safety and effectiveness of the HARPOON™ System in the treatment of patients with severe degenerative mitral regurgitation (DMR).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Konstantinos Koulogiannis, MD
Department of Cardiovascular Medicine Gagnon Cardiovascular Institute
Principal Investigator
clinicaltrials.gov ↗
Vinod H. Thourani, MD
Dept of Cardiovascular Surgery, Piedmont Heart Institute
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Ucsf
San Francisco, California, United States
Piedmont Heart Institute
Atlanta, Georgia, United States
Johns Hopkins
Baltimore, Maryland, United States
University of Maryland Medical Center
Baltimore, Maryland, United States
University of Michigan Health System
Ann Arbor, Michigan, United States
Mayo Clinic
Rochester, Minnesota, United States
Ohsu Knight Cardiovascular Institute
Portland, Oregon, United States
Centennial Medical Center
Nashville, Tennessee, United States
Intermountain Heart Institute
Murray, Utah, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 16 Dec 2020
Primary completion: 20 Dec 2027
Completion: 20 Dec 2027
Last update posted: 19 Aug 2026
Registered enrollment: 25
Registry id: NCT04375332

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.