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Clinical trialNCT04453293TerminatedPhase 3Interventional

Immunization With BCG Vaccine to Prevent Tuberculosis Infection

SponsorHenry M. Jackson Foundation for the Advancement of Military MedicineEnrollment16Tuberculosis Infection
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this research is to find out if a single dose of pre-travel vaccination with BCG can lessen tuberculosis (TB) infection by producing an immune response when given to adults traveling to countries with a high or moderate burden of TB. BCG will be compared with a placebo (an inactive vaccine). BCG (Japan) is used globally but is not approved for use in the United States, therefore it is considered experimental. Participants choosing to take part in this research study, will be randomly assigned (this is like a coin flip) to BCG or placebo. 2000 eligible volunteers will be enrolled.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • Merlin L. Robb, MD

    Henry M. Jackson Foundation for the Advancement of Military Medicine

    Study Director
    clinicaltrials.gov ↗
  • Naomi E. Aronson, MD

    Uniformed Services University of the Health Sciences

    Study Chair
    clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Yale University School of Medicine

    New Haven, Connecticut, United States

  • Medstar Washington Hospital Center/medstar Health Research Institute

    Washington D.C., District of Columbia, United States

  • Hope Clinic of the Emory University Vaccine Center, Emory University

    Decatur, Georgia, United States

  • Johns Hopkins Bloomberg School of Public Health, Department of International Health, Center for Immunization Research

    Baltimore, Maryland, United States

  • the Brigham and Women'S Hospital Center for Clinical Investigation

    Boston, Massachusetts, United States

  • Baylor College of Medicine

    Houston, Texas, United States

  • University of Utah School of Medicine

    Salt Lake City, Utah, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

BACILLUS CALMETTE-GUERIN VACCINEPlacebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
1 Dec 2021
Primary completion
16 Jan 2026
Completion
16 Jan 2026
Last update posted
23 Jan 2026
Registered enrollment
16
Registry id
NCT04453293
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.