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Clinical trialNCT04466683Active, not recruitingPhase 2Interventional

Low-Dose Radiotherapy For Patients With SARS-COV-2 (COVID-19) Pneumonia

SponsorOhio State UniversityEnrollment37Covid-19PneumoniaSars-CoV2
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Low doses of radiation in the form of chest x-rays has been in the past to treat people with pneumonia. This treatment was thought to reduce inflammation and was found to be effective without side effects. However, it was an expensive treatment and was eventually replaced with less expensive treatment options like penicillin. The COVID-19 virus has emerged recently, causing high rates of pneumonia in people. The authors believe that giving a small dose of radiation to the lungs may reduce inflammation and neutralize the pneumonia caused by COVID-19. For this study, the x-ray given is called radiation therapy. Radiation therapy uses high-energy X-ray beams from a large machine to target the lungs and reduce inflammation. Usually, it is given at much higher doses to treat cancers. The purpose of this study is to find out if adding a single treatment of low-dose x-rays to the lungs might reduce the amount of inflammation in the lungs from COVID-19 infection, which could reduce the need for a ventilator or breathing tube.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • Arnab Chakravarti, MD

    James Cancer Hospital, Department of Radiation Oncology

    Principal Investigator

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Colombia
  • Hospital Universitario San Ignacio

    Bogotá, Colombia

United States
  • Boca Raton Regional Hospital Lynn Cancer Institute

    Boca Raton, Florida, United States

  • Miami Cancer Institute

    Miami, Florida, United States

  • Loyola University Chicago

    Maywood, Illinois, United States

  • Indiana University School of Medicine

    Indianapolis, Indiana, United States

  • Lowell General Hospital Cancer Center

    Lowell, Massachusetts, United States

  • Ohio State University James Cancer Hospital

    Columbus, Ohio, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
28 Aug 2020
Primary completion
31 Dec 2026
Completion
31 Dec 2026
Last update posted
16 Apr 2026
Registered enrollment
37
Registry id
NCT04466683

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.