Clinical trialNCT04518059CompletedObservational

Misfolded Proteins in the Skin of People With Parkinson's Disease and Other Parkinsonism

SponsorUniversity Hospitals Cleveland Medical CenterEnrollment184Corticobasal DegenerationDementia With Lewy BodiesMultiple System AtrophyParkinson DiseaseParkinsonismProgressive Supranuclear Palsy

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to determine whether identification of misfolded proteins in the skin will help to determine what sort of parkinsonism someone has. We seek to demonstrate whether someone has a synucleinopathy such as Parkinson's disease (PD), multiple system atrophy (MSA), or dementia with Lewy bodies(DLB), as opposed to a tauopathy such as progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD) or no parkinsonism at all (control).

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Chen Shu, PhD
University of Alabama at Birmingham
Principal Investigator
clinicaltrials.gov ↗
Qingzhong Kong, PhD
Case Western Reserve University
Principal Investigator
clinicaltrials.gov ↗
Steven Gunzler, MD
University Hospitals Cleveland Medical Center and Case Western Reserve University
Principal Investigator
clinicaltrials.gov ↗
Zerui Wang, MD, PhD
Case Western Reserve University
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
University Hospitals Suburban Health Center
South Euclid, Ohio, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 12 Mar 2019
Primary completion: 31 May 2025
Completion: 31 May 2025
Last update posted: 1 Jul 2025
Registered enrollment: 184
Registry id: NCT04518059

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.