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Clinical trialNCT04521946WithdrawnPhase 1Interventional

Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer

SponsorM.D. Anderson Cancer CenterEnrollment0Anaplastic EpendymomaAtypical Teratoid/Rhabdoid TumorCentral Nervous System Germ Cell TumorChoroid Plexus CarcinomaIntracranial Myeloid SarcomaMalignant Brain Neoplasm+9 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase I trial investigates the side effects and effectiveness of chemotherapy followed by a donor (allogeneic) stem cell transplant when given to patients with high grade brain cancer. Chemotherapy drugs, such as fludarabine, thiotepa, etoposide, melphalan, and rabbit anti-thymocyte globulin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy before a donor stem cell transplant helps kill cancer cells in the body and helps make room in the patient's bone marrow for new blood-forming cells (stem cells) to grow. When the healthy stem cells from a donor are infused into a patient, they may help the patient's bone marrow make more healthy cells and platelets and may help destroy any remaining cancer cells.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

No facility list is in our current data snapshot for this study. The registry record on ClinicalTrials.gov ↗ carries any published locations. Why? →

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Etoposide →Fludarabine →Lymphocyte immune globulin, anti-thymocyte globulin →Melphalan →Mycophenolate mofetil →Tacrolimus →Thiotepa
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
14 Jan 2021
Primary completion
20 Dec 2022
Completion
20 Dec 2022
Last update posted
26 Oct 2024
Registered enrollment
0
Registry id
NCT04521946
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.